… Dr David C Rees, FRCP David C Rees … Correspondence to: Dr David C Rees, Department
of Paediatric Haematology, King's College Hospital NHS Foundation Trust, Denmark Hill, …

We have analysed 3380 chromosomes (1690 unrelated individuals) from twenty-four populations
for the presence of factor V Leiden, an important risk factor in venous thromboembolism…

Fragment-based lead discovery is gaining momentum in both large pharmaceutical companies
and biotechnology laboratories as a complementary approach to traditional screening. …

Despite decades of ground-breaking research in academia, organic synthesis is still a rate-limiting
factor in drug-discovery projects. Here we present some current challenges in …

Sickle cell disease is caused by an alteration in a single DNA base, but its clinical
manifestations are influenced by other genes and behavioral and environmental factors. Recent …

The judicious application of ligand or binding efficiency metrics, which quantify the molecular
properties required to obtain binding affinity for a drug target, is gaining traction in the …

The search for new drugs is plagued by high attrition rates at all stages in research and
development. Chemists have an opportunity to tackle this problem because attrition can be …

This work covers the identity, biology and ecology of pests of stored products. These insects
are of considerable economic importance. Part field guide, part office reference, it lays out …

The previous network model of polymer gel structure is now revised to take account of new
evidence that different levels of chain association may be involved in the cross-linking …

A mutant allele of the β-chemokine receptor gene CCR5 bearing a 32-basepair (bp) deletion
(denoted Δccr5) which prevents cell invasion by the primary transmitting strain of HIV-1 has …