Large-scale reference data sets of human genetic variation are critical for the medical and
functional interpretation of DNA sequence changes. Here we describe the aggregation and …

Background: Thyroid nodules are a common clinical problem, and differentiated thyroid
cancer is becoming increasingly prevalent. Since the publication of the American Thyroid …

An effective vaccine is needed to halt the spread of the severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) pandemic. Recently, we reported safety, tolerability and …

Model-based vision is firmly established as a robust approach to recognizing and locating
known rigid objects in the presence of noise, clutter, and occlusion. It is more problematic to …

Background Whether vaccination during pregnancy could reduce the burden of respiratory
syncytial virus (RSV)–associated lower respiratory tract illness in newborns and infants is …

We compared the predictions of the web versions of MutationTaster2, SIFT (http://sift. jcvi. org/),
PolyPhen-2 (http://genetics. bwh. harvard. edu/pph2/) and PROVEAN (http://provean. jcvi. …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and
the resulting coronavirus disease 2019 (Covid-19) have afflicted tens of millions of people in …

Objective: To describe a syndrome of peripheral lipodystrophy (fat wasting of the face, limbs
and upper trunk), hyperlipidaemia and insulin resistance in patients receiving potent HIV …

Background BNT162b2 is a lipid nanoparticle–formulated, nucleoside-modified RNA vaccine
encoding a prefusion-stabilized, membrane-anchored severe acute respiratory syndrome …

BNT162b2, a nucleoside-modified mRNA formulated in lipid nanoparticles that encodes the
SARS-CoV-2 spike glycoprotein (S) stabilized in its prefusion conformation, has …