Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …

Recent genomic profiling of childhood acute lymphoblastic leukemia (ALL) identified a high-risk
subtype with an expression signature resembling that of Philadelphia chromosome–…

Balancing selection is potentially an important biological force for maintaining advantageous
genetic diversity in populations, including variation that is responsible for long-term …

A growing number of genes involved in sex and reproduction have been demonstrated to
be rapidly evolving. Here, we show that genes expressed solely in spermatozoa represent a …

Motivation: It is becoming increasingly evident that the analysis of genotype data from recently
admixed populations is providing important insights into medical genetics and population …

Background Acute lymphoblastic leukemia (ALL) is the most common cancer in children
and the incidence of ALL varies by ethnicity. Although accumulating evidence indicates …

Genomic imprinting is an important regulatory mechanism that silences one of the parental
copies of a gene. To systematically characterize this phenomenon, we analyze tissue …

Purpose Recent genome-wide screens have identified genetic variations in ARID5B
associated with susceptibility to childhood acute lymphoblastic leukemia (ALL). We sought to …

10.7554/eLife.20532.001 Populations are often divided categorically into distinct racial/ethnic
groups based on social rather than biological constructs. Genetic ancestry has been …

Past demographic changes can produce distortions in patterns of genetic variation that can
mimic the appearance of natural selection unless the demographic effects are explicitly …