User profiles for Danny J. Eckert

Danny Eckert

Adelaide Institute for Sleep Health, Flinders University and Neuroscience Research …
Verified email at flinders.edu.au
Cited by 13382

Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets

DJ Eckert, DP White, AS Jordan, A Malhotra… - American journal of …, 2013 - atsjournals.org
Rationale: The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among
patients but have not been well characterized. Objectives: To define carefully the proportion …

Pathophysiology of adult obstructive sleep apnea

DJ Eckert, A Malhotra - Proceedings of the American thoracic …, 2008 - atsjournals.org
Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive narrowing
or collapse of the pharyngeal airway during sleep. The disorder is associated with major …

Central sleep apnea: pathophysiology and treatment

DJ Eckert, AS Jordan, P Merchia, A Malhotra - Chest, 2007 - Elsevier
Central sleep apnea (CSA) is characterized by a lack of drive to breathe during sleep,
resulting in repetitive periods of insufficient ventilation and compromised gas exchange. These …

Phenotypic approaches to obstructive sleep apnoea–new pathways for targeted therapy

DJ Eckert - Sleep medicine reviews, 2018 - Elsevier
People develop obstructive sleep apnoea (OSA) for different reasons. The ability to understand
these reasons, easily identify them in individual patients, and develop therapies that …

Obstructive sleep apnea: current perspectives

…, SG Carter, JC Carberry, DJ Eckert - Nature and science of …, 2018 - Taylor & Francis
The prevalence of obstructive sleep apnea (OSA) continues to rise. So too do the health,
safety, and economic consequences. On an individual level, the causes and consequences of …

Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold

DJ Eckert, RL Owens, GB Kehlmann… - Clinical …, 2011 - portlandpress.com
Recent insights into sleep apnoea pathogenesis reveal that a low respiratory arousal
threshold (awaken easily) is important for many patients. As most patients experience stable …

Treating obstructive sleep apnea with hypoglossal nerve stimulation

…, CE Palme, S Robinson, GS Goding, DJ Eckert… - Sleep, 2011 - academic.oup.com
Background: Reduced upper airway muscle activity during sleep is fundamental to obstructive
sleep apnea (OSA) pathogenesis. Hypoglossal nerve stimulation (HGNS) counteracts this …

Arousal from sleep: implications for obstructive sleep apnea pathogenesis and treatment

DJ Eckert, MK Younes - Journal of Applied Physiology, 2014 - journals.physiology.org
Historically, brief awakenings from sleep (cortical arousals) have been assumed to be vitally
important in restoring airflow and blood-gas disturbances at the end of obstructive sleep …

Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea

BA Edwards, SA Sands, DJ Eckert… - The Journal of …, 2012 - Wiley Online Library
Key points • Obstructive sleep apnoea (OSA) probably results from the interaction of key
pathophysiological traits including compromised pharyngeal anatomy, inadequate upper‐…

A method for measuring and modeling the physiological traits causing obstructive sleep apnea

A Wellman, DJ Eckert, AS Jordan… - Journal of applied …, 2011 - journals.physiology.org
There is not a clinically available technique for measuring the physiological traits causing
obstructive sleep apnea (OSA). Therefore, it is often difficult to determine why an individual has …