Salmonella pathogenicity island 2 (SPI‐2) encodes a putative type III secretion system necessary
for systemic infection in animals. We have investigated the transcriptional organization …

Generalist and specialist species differ in the breadth of their ecological niches. Little is known
about the niche width of obligate human pathogens. Here we analyzed a global collection …

The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis
(TB) substantially challenges TB control, especially in the European Region of the World …

Background Pyrazinamide and fluoroquinolones are essential antituberculosis drugs in new
rifampicin-sparing regimens. However, little information about the extent of resistance to …

Scope Several methods are used worldwide for antibiotic susceptibility testing (AST) for the
Mycobacterium tuberculosis complex (MTBC). The variability in the results obtained with …

Background Molecular diagnostics are considered the most promising route to achievement
of rapid, universal drug susceptibility testing for Mycobacterium tuberculosis complex (MTBC…

The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention
and rehabilitation requires frequent update of existing guidelines. This review is aimed at …

Analyzing whole-genome sequencing data of Mycobacterium tuberculosis complex (MTBC)
isolates in a standardized workflow enables both comprehensive antibiotic resistance …

Background In many countries, regular monitoring of the emergence of resistance to anti-tuberculosis
drugs is hampered by the limitations of phenotypic testing for drug susceptibility. …

To accelerate the fight against tuberculosis, major diagnostic challenges need to be addressed
urgently. Post-2015 targets are unlikely to be met without the use of novel diagnostics …