Upon binding of cortisol, the glucocorticoid receptor (GR) regulates the transcription of
specific target genes, including those that encode the stress hormones corticotropin-releasing …

Sphingosine-1-phosphate (S1P) is a widespread lysophospholipid which displays a wealth
of biological effects. Extracellular S1P conveys its activity through five specific G-protein …

Niemann–Pick disease type C (NP-C) is a rare, autosomal-recessive, progressive neurological
disease caused by mutations in either the NPC1 gene (in 95% of cases) or the NPC2 …

The gas-phase valence binding energy spectrum of isolated ion-pairs of the commonly used
[1-ethyl-3-methylimidazolium][bis(trifluoromethylsulfonyl)imide)] room-temperature ionic …

Using a new type of ion trap, we demonstrate that the length of a packet of charged particles
oscillating between two electrostatic mirrors will remain constant under special conditions. …

We describe a new mass spectrometric technique that is based on the use of a linear
electrostatic ion trap and a newly discovered self-bunching phenomenon. Ions are stored in the …

Aims The main objectives of these two phase I studies were to investigate safety and
tolerability as well as the pharmacokinetic/pharmacodynamic profile of the novel potent and …

Endothelin (ET) receptor antagonists have been associated with fluid retention. It has been
suggested that, of the two endothelin receptor subtypes, ET B receptors should not be …

The CXCR3 chemokine receptor is a G protein-coupled receptor mainly expressed on
immune cells from the lymphoid lineage, including activated T cells. Binding of its inducible …

The time scales and formation mechanisms of tri-hydrogen cation products in organic molecule
ionization processes are poorly understood, despite their cardinal role in the chemistry of …