Recommendations for a standardized pulmonary function report. An official American Thoracic Society technical statement
…, M Rosenfeld, S Stanojevic, DJ Weiner - American journal of …, 2017 - atsjournals.org
Background: The American Thoracic Society committee on Proficiency Standards for Pulmonary
Function Laboratories has recognized the need for a standardized reporting format for …
Function Laboratories has recognized the need for a standardized reporting format for …
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation.
We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of …
We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of …
Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity
Disease-associated single-nucleotide polymorphisms (SNPs) generally do not implicate target
genes, as most disease SNPs are regulatory. Many SNP-to-gene (S2G) linking strategies …
genes, as most disease SNPs are regulatory. Many SNP-to-gene (S2G) linking strategies …
Polygenic architecture of rare coding variation across 394,783 exomes
Both common and rare genetic variants influence complex traits and common diseases.
Genome-wide association studies have identified thousands of common-variant associations, …
Genome-wide association studies have identified thousands of common-variant associations, …
Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide
Antimicrobial peptides, such as defensins or cathelicidins, are effector substances of the
innate immune system and are thought to have antimicrobial properties that contribute to host …
innate immune system and are thought to have antimicrobial properties that contribute to host …
Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in vivo
GP Kobinger, DJ Weiner, QC Yu, JM Wilson - Nature biotechnology, 2001 - nature.com
Traditional gene therapy vectors have demonstrated limited utility for treatment of chronic
lung diseases such as cystic fibrosis (CF). Herein we describe a vector based on a Filovirus …
lung diseases such as cystic fibrosis (CF). Herein we describe a vector based on a Filovirus …
Assessment of clinical response to ivacaftor with lung clearance index in cystic fibrosis patients with a G551D-CFTR mutation and preserved spirometry: a randomised …
Background Ivacaftor has shown a clinical benefit in patients with cystic fibrosis who have
the G551D-CFTR mutation and reduced lung function. Lung clearance index (LCI) using …
the G551D-CFTR mutation and reduced lung function. Lung clearance index (LCI) using …
Obesity and airway dysanapsis in children with and without asthma
Rationale: For unclear reasons, obese children with asthma have higher morbidity and reduced
response to inhaled corticosteroids. Objectives: To assess whether childhood obesity is …
response to inhaled corticosteroids. Objectives: To assess whether childhood obesity is …
Use of the mechanical in-exsufflator in pediatric patients with neuromuscular disease and impaired cough
LJ Miske, EM Hickey, SM Kolb, DJ Weiner, HB Panitch - Chest, 2004 - Elsevier
Background Impaired cough secondary to weakness from neuromuscular disease (NMD)
can cause serious respiratory complications, including atelectasis, pneumonia, small airway …
can cause serious respiratory complications, including atelectasis, pneumonia, small airway …
Measurement of FEF25–75% and FEF75% does not contribute to clinical decision making
The aim of this study was to determine the added value of measuring the forced expiratory
flow at 25–75% of forced vital capacity (FVC) (FEF 25–75% ) and flow when 75% of FVC has …
flow at 25–75% of forced vital capacity (FVC) (FEF 25–75% ) and flow when 75% of FVC has …