[HTML][HTML] Inhibition of Exercise-Induced Bronchoconstriction by MK-571, a Potent Leukotriene D4–Receptor Antagonist

PJ Manning, RM Watson, DJ Margolskee… - … England Journal of …, 1990 - Mass Medical Soc
Background. Exercise is a common stimulus of bronchoconstriction in subjects with asthma,
who also have bronchoconstriction after inhaling the sulfidopeptide leukotriene D 4 (LTD 4 ). …

The leukotriene-receptor antagonist MK-0679 blocks airway obstruction induced by inhaled lysine-aspirin in aspirin-sensitive asthmatics

B Dahlen, M Kumlin, DJ Margolskee… - European …, 1993 - Eur Respiratory Soc
Drugs which block the action or formation of the cysteinyl leukotrienes (LTC4, LTD4 and LTE4)
inhibit asthmatic responses evoked by allergen, exercise and cold dry air. The purpose of …

Bronchodilation with a potent and selective leukotriene D4 (LTD4) receptor antagonist (MK-571) in patients with asthma

JN Gaddy, DJ Margolskee, RK Bush… - Am Rev Respir …, 1992 - atsjournals.org
The sulfldopeptlde leukotrlenes LTC4, LTD4, and LTE4 can cause airway smooth muscle
contraction and have been Implicated In the pathophysiology of asthma. MK-571 Is a selective, …

Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects.

B Dahlen, DJ Margolskee, O Zetterström, SE Dahlen - Thorax, 1993 - thorax.bmj.com
BACKGROUND--The cysteinyl leukotrienes (LTC4, LTD4, and LTE4) have been shown to
mediate airway obstruction evoked by several factors which trigger asthmatic reactions--for …

Leukotriene D4 receptor blockade inhibits the immediate and late bronchoconstrictor responses to inhaled antigen in patients with asthma

JB Rasmussen, LO Eriksson, DJ Margolskee… - Journal of allergy and …, 1992 - Elsevier
We have tested the hypothesis that leukotriene D 4 (LTD 4 ) receptor activation is involved
in the development of antigen-induced bronchoconstriction. In two studies, patients with …

MK-571, a potent antagonist of leukotriene D4-induced bronchoconstriction in the human

JC Kips, GF Joos, I De Lepeleire, DJ Margolskee… - Am Rev Respir …, 1991 - atsjournals.org
MK-571is a novelleukotriene D./E.(LTD./E.) receptor antagonist. The ability of MK-571 to inhibit
LTD.-induced bronchoconstriction was examined both in six healthy volunteers and in six …

Indomethacin blocks airway tolerance to repetitive exercise but not to eucapnic hyperpnea in asthmatic subjects

DJ Margolskee, BG Bigby, HA Boushey - Am Rev Respir Dis, 1988 - atsjournals.org
We have examined the effects of indomethacin (I) on tolerance to the bronchomotor effects
of repetitive challenge with exercise (EX) and eucapnic hyperpnea (EH) in 7 asthmatic …

Dose-dependent kinetics of the enantiomers of MK-571, an LTD4-receptor antagonist

M Depré, DJ Margolskee, A Van Hecken… - European journal of …, 1992 - Springer
The disposition of the enantiomers of MK-571 (MK-0679 and L-668,018) following single iv
doses of MK-571 (L-660,711) was studied in a three way cross-over study in 12 healthy male …

Plasma drug profiles and tolerability of MK-571 (L-660,711), a leukotriene D4 receptor antagonist, in man

M Depre, DJ Margolskee, JYK Hsieh… - European journal of …, 1992 - Springer
We have studied the tolerability and plasma drug profiles of a leukotriene D4 receptor
antagonist, MK-571, given intravenously and as an oral solution in two separate trials. Study I (iv) …

Urinary LTE4 excretion in antigen‐provoked asthmatic patients treated with the inhaled LTD4 antagonist, L‐648,051

JB Rasmussen, LO Eriksson, P Tagari, DJ Margolskee… - Allergy, 1992 - Wiley Online Library
Leukotriene (LT) E 4 represents the major LT metabolite in man, and its urinary excretion can
be used as an indirect marker of systemic LTC 4 and/or LTD 4 synthesis and release. In the …