Sleep in chronic obstructive lung disease

DC Flenley - Clinics in chest medicine, 1985 - Elsevier
Profound transient nocturnal hypoxemia is common during REM sleep in “blue bloaters”
with chronic obstructive lung disease, these patients having hypoxemia and CO 2 retention …

CT measurements of lung density in life can quantitate distal airspace enlargement—an essential defining feature of human emphysema

…, A Redpath, JJK Best, D Lamb, DC Flenley - American Review of …, 1988 - atsjournals.org
We used a computerized microscopic image analysis system to directly measure the surface
area of distal air spaces in methacrylate-embedded blocks randomly selected from inflation-…

Diagnosis of pulmonary emphysema by computerised tomography

MD Hayhurst, DC Flenley, A McLean, AJA Wightman… - The Lancet, 1984 - Elsevier
Eleven patients with peripheral bronchial carcinoma had computerised tomographic (CT)
scans before operation. The resected specimens from six of these patients showed mild centri-…

The effect of oxygenation on sleep quality in chronic bronchitis and emphysema

…, NJ Douglas, JR Catterall, DC Flenley - American Review of …, 1982 - atsjournals.org
We recorded the electroencephalogram, electrooculogram, electromyogram, and ear oxygen
saturation (Sa O 2 ) during sleep in 20 patients with chronic bronchitis and emphysema, 13 …

Lung CT density correlates with measurements of airflow limitation and the diffusing capacity

…, PM Warren, JJ Best, DC Flenley… - European …, 1991 - Eur Respiratory Soc
We studied 80 subjects (63 M, 17 F; 23-82 yrs) and related lung computerized tomography (CT)
density with age, height, spirometry, lung volumes, diffusing capacity and arterial blood …

Acute hypercapnic respiratory failure in patients with chronic obstructive lung disease: risk factors and use of guidelines for management.

AA Jeffrey, PM Warren, DC Flenley - Thorax, 1992 - thorax.bmj.com
… , Edinburgh EH10 5SB AA Jeffrey PM Warren DC Flenley Reprint requests to: Dr Warren
Accepted 10 September 1991 *Professor Flenley died shortly after completion of the study …

Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine.

MM Bridgeman, M Marsden, W MacNee, DC Flenley… - Thorax, 1991 - thorax.bmj.com
N-acetylcysteine (600 mg/day) was given to patients by mouth for five days before bronchoscopy
and bronchoalveolar lavage to determine whether N-acetylcysteine could increase the …

Transient hypoxaemia during sleep in chronic bronchitis and emphysema

…, PMA Calverley, RJE Leggett, HM Brash, DC Flenley… - The Lancet, 1979 - Elsevier
Arterial oxygenation, breathing pattern, and electroencephalogram were studied during sleep
in patients with chronic bronchitis and emphysema and in healthy subjects. All of the 10 "…

Transient hypoxemia during sleep in chronic obstructive pulmonary disease is not a sleep apnea syndrome

…, V Brezinova, HM Brash, DC Flenley - American Review of …, 1983 - atsjournals.org
We measured ear oxygen saturation (Sa O 2 ), chest wall movement, and oronasal air flow,
and took electroencephalographic tracings during nocturnal sleep in 20 healthy subjects and …

Respiratory failure revisited: acute exacerbations of chronic bronchitis between 1961-68 and 1970-76

PM Warren, JS Millar, DC Flenley, A Avery - The Lancet, 1980 - Elsevier
Factors determining survival have been analysed retrospectively in 157 admissions of 135
patients with an acute exacerbation of chronic bronchitis and emphysema causing …