Raloxifene: a selective estrogen receptor modulator (SERM) with multiple target system effects

DB Muchmore - The Oncologist, 2000 - academic.oup.com
… Patients were randomly assigned to receive raloxifene 60 mg/d, raloxifene 120 mg/d, or
placebo. All reported breast cancers were confirmed by pathology report, and, whenever …

Continued breast cancer risk reduction in postmenopausal women treated with raloxifene: 4-year results from the MORE trial

…, SL Silfen, EL Walls, H Schmitt, DB Muchmore… - Breast cancer research …, 2001 - Springer
… All women received 500 mg/day calcium supplementation and 400– 600 IU of vitamin D.
The sponsor supplied randomly numbered kits containing identically appearing raloxifene and …

Ultrafast-acting insulins: state of the art

L Heinemann, DB Muchmore - Journal of diabetes science …, 2012 - journals.sagepub.com
Optimal coverage of prandial insulin requirements remains an elusive goal. The invention of
rapid-acting insulin analogs (RAIAs) was a big step forward in reducing postprandial …

[3] Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance

DC Muchmore, LP McIntosh, CB Russell… - Methods in …, 1989 - Elsevier
Publisher Summary This chapter discusses the methods of biosynthetic enrichment of
proteins with 15 N in backbone and side-chain groups, as exemplified by the work with …

Use of recombinant human hyaluronidase to accelerate rapid insulin analogue absorption: experience with subcutaneous injection and continuous infusion

DE Vaughn, DB Muchmore - Endocrine Practice, 2011 - Elsevier
D, Fourteen volunteers received 0.15 U/kg, with the following results: AUC 0 60 291%, C
210%, T -26 minutes, and AUC > 2h 53%; G 1h 232%, G 2h 161%, onset of action -16 minutes, …

Temperature-sensitive mutations of bacteriophage T4 lysozyme occur at sites with low mobility and low solvent accessibility in the folded protein

T Alber, DP Sun, JA Nye, DC Muchmore… - Biochemistry, 1987 - ACS Publications
… assay was used to screen for reduced lysozyme production at increasing growth
temperatures (D. C. Muchmore, unpublished results; Alber & Matthews, 1987). Cloning and DNA …

Glimepiride, a new once-daily sulfonylurea: a double-blind placebo-controlled study of NIDDM patients

J Rosenstock, E Samols, DB Muchmore… - Diabetes …, 1996 - Am Diabetes Assoc
OBJECTIVE To compare the efficacy and safety of two daily doses of the new sulfonylurea,
glimepiride (Amaryl), each as a once-daily dose or in two divided doses, in patients with …

Self-monitoring of blood glucose in overweight type 2 diabetic patients

DB Muchmore, J Springer, M Miller - Acta diabetologica, 1994 - Springer
… Newman W, Laqua D, Engelbrecht D, Impact of glucose selfmonitoring on glycohemoglobin
values in a veteran population. Arch Int Med 150:107-110, 1990 7. Allen B, DeLong E, …

A comparison of the effects of raloxifene and estrogen on bone in postmenopausal women

…, M Gunness, DB Muchmore… - The Journal of …, 2000 - academic.oup.com
Raloxifene HCl, a selective estrogen receptor modulator, has been shown to increase bone
mineral density (BMD) and decrease biochemical markers of bone turnover in …

N, N, N', N'-Tetramethylphosphorodiamidate group. Useful function for the protection or reductive deoxygenation of alcohols and ketones

RE Ireland, DC Muchmore… - Journal of the American …, 1972 - ACS Publications
We recently reported2 that the lithium-amine reduction of enol diethyl phosphates prepared
by phos-phorylation ofenolate anions was an efficient method for the regiospecific formation …