In the recent era, no congenital heart defect has undergone a more dramatic change in
diagnostic approach, management, and outcomes than hypoplastic left heart syndrome (HLHS). …

Pulmonary hypertension (PH) is a rare disease in newborns, infants, and children that is
associated with significant morbidity and mortality. In the majority of pediatric patients, PH is …

Paediatric pulmonary arterial hypertension (PAH) shares common features of adult disease,
but is associated with several additional disorders and challenges that require unique …

Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic
diseases in neonates, infants, and older children and contributes to significant morbidity and …

Background Paediatric pulmonary hypertension, is an important cause of morbidity and
mortality, and is insufficiently characterised in children. The Tracking Outcomes and Practice in …

Background— Safe, effective therapy is needed for pediatric pulmonary arterial hypertension.
Methods and Results— Children (n=235; weight ≥8 kg) were randomized to low-, medium…

Background— Pulmonary arterial hypertension (PAH) is a rare but important cause of morbidity
and mortality in children. Methods and Results— We analyzed data from 216 patients ≤…

RhoA GTPase mediates a variety of cellular responses, including activation of the contractile
apparatus, growth, and gene expression. Acute hypoxia activates RhoA and, in turn, its …

Objectives : This study investigated the long-term outcome of children with pulmonary arterial
hypertension (PAH) treated with bosentan therapy, with or without concomitant prostanoid …

OBJECTIVE: To determine the clinical course and outcomes of infants with chronic lung
disease (CLD) and pulmonary hypertension (PH) who received prolonged sildenafil therapy. …