Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally, …

… & Alvaro, D. Multiple cells of origin in cholangiocarcinoma underlie biological, … & Alvaro,
D. Cholangiocarcinoma: a cancer in search of the right classification. Hepatology 56, 1585–1586…

… Comments on biliary tree biology & cholangiocytes were written & edited by D. Alvaro, E. …
(D,E) EpCAM expression in adult liver: one end of the Canal of Hering connects to the bile duct, …

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor
prognosis and limited treatment options. Here, we describe the integrated analysis of somatic …

Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to
fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation 1 , 2 , …

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in
an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB …

… (C,D) The type 2 colonies are comprised of undulating, swirling cells with EpCAM expression
at the edges but not interiors of the colonies and with high levels of expression of SOX17, …

Background & Aims Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer,
whose incidence and related mortality is increasing. This study investigates the clinical …

… (B) After perfusion wash with basal medium for 10 minutes the liver becomes pale; (C) during
delipidation, the liver becomes partially transparent under GC; (D) final intact scaffold looks …

… Docosahexanoic acid plus vitamin D treatment improves features of NAFLD in children
with serum vitamin d deficiency: results from a single centre trial. PLoS One 2016;11:e0168216. …