Background Obesity is a common risk factor for polycystic ovary syndrome (PCOS) and
obstructive sleep apnoea (OSA). Both PCOS and OSA are associated with increased risk of type …

Assessment of emphysema-modifying therapy is difficult, but newer outcome measures offer
advantages over traditional methods. The EXAcerbations and Computed Tomography scan …

Rationale: α 1 -Antitrypsin (AAT) deficiency is associated with increased risk of chronic
obstructive pulmonary disease (COPD), in particular emphysema, but airway disease is less well …

FEV 1 is fundamental to the diagnosis and staging of chronic obstructive pulmonary disease.
In emphysema, airflow obstruction usually coexists with impairment of gas exchange, but …

… David G Parr has served on company advisory board meetings for Talecris Biotherapeutics
and acts as a consultant on the technical steering committees of Talecris Biotherapeutics and …

Background: Lung densitometry derived from computed tomographic images offers an
opportunity to quantify emphysema non-invasively, but a pathological standard cannot be applied …

In patients with airflow limitation caused by cigarette smoking, lung density measured by
computed tomography is strongly correlated with quantitative pathology scores of emphysema, …

Background Computed tomography (CT) lung densitometry has been demonstrated to be
the most sensitive and specific outcome measure for the assessment of emphysema-modifying …

Rationale: Neutrophilic inflammation is understood to be of pathogenetic importance in
chronic obstructive pulmonary disease (COPD) and may be quantified using 18-…

The fundamental importance of calibration for any measuring device is indisputable, but
computed tomography (CT) calibration in longitudinal lung densitometry studies is largely …