Objective. —To examine more closely the association between apolipoprotein E (APOE)
genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and …

The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1
mutations are associated with PARK7, a monogenic form of human parkinsonism. The function …

Background Sequence variants, including the ε4 allele of apolipoprotein E, have been
associated with the risk of the common late-onset form of Alzheimer's disease. Few rare variants …

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …

Here we describe an R library for genome-wide association (GWA) analysis. It implements
effective storage and handling of GWA data, fast procedures for genetic data quality control, …

Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated
with interindividual blood pressure variation have been identified and replicated. Here we …

To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium
curated and analyzed genome-wide genotypes and 16S fecal microbiome data from …

Context Genome-wide association studies (GWAS) have recently identified CLU, PICALM,
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …

Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the
elderly, with limited therapeutic options. Here we report on a study of >12 million variants, …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …