[HTML][HTML] A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection
Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial cells for
SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion with the …
SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion with the …
[HTML][HTML] Signs of immunosenescence correlate with poor outcome of mRNA COVID-19 vaccination in older adults
MÁ Palacios-Pedrero, JM Jansen, C Blume… - Nature Aging, 2022 - nature.com
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
effective in preventing COVID-19 hospitalization and fatal outcome. However, several studies …
effective in preventing COVID-19 hospitalization and fatal outcome. However, several studies …
In vitro and ex vivo models of human asthma
Asthma is an inflammatory disorder of the conducting airways which undergo distinct
structural and functional changes leading to non-specific bronchial hyperresponsiveness (BHR) …
structural and functional changes leading to non-specific bronchial hyperresponsiveness (BHR) …
[HTML][HTML] Autoimmunity in CD73/Ecto-5′-nucleotidase deficient mice induces renal injury
Extracellular adenosine formed by 5′-ectonucleotidase (CD73) is involved in tubulo-glomerular
feedback in the kidney but is also known to be an important immune modulator. Since …
feedback in the kidney but is also known to be an important immune modulator. Since …
Cerivastatin inhibits proliferation of interleukin-1β-induced rat mesangial cells by enhanced formation of nitric oxide
C Blume, D Sabuda-Widemann, J Pfeilschifter… - European journal of …, 2004 - Elsevier
The antiproliferative effect of statins on mesangial cells could represent a new therapeutic
approach in glomerulonephritis. We studied in rat mesangial cells whether the antiproliferative …
approach in glomerulonephritis. We studied in rat mesangial cells whether the antiproliferative …
Hydrogels for 3D mammalian cell culture: a starting guide for laboratory practice
F Ruedinger, A Lavrentieva, C Blume… - Applied microbiology …, 2015 - Springer
Hydrogels have become one of the most popular platforms for three-dimensional (3D) cultivation
of mammalian cells. The enormous versatility of hydrogel materials makes it possible to …
of mammalian cells. The enormous versatility of hydrogel materials makes it possible to …
Increase of infectious complications in ABO-incompatible kidney transplant recipients—a single centre experience
A Habicht, V Bröker, C Blume… - Nephrology Dialysis …, 2011 - academic.oup.com
Background. Due to the shortage of deceased donors ABO-incompatible (ABOi) living kidney
transplantation has become a popular alternative to deceased kidney transplantation. In …
transplantation has become a popular alternative to deceased kidney transplantation. In …
Pollen exposure weakens innate defense against respiratory viruses
Background Hundreds of plant species release their pollen into the air every year during
early spring. During that period, pollen allergic as well as non‐allergic patients frequently …
early spring. During that period, pollen allergic as well as non‐allergic patients frequently …
[HTML][HTML] TNF-α–mediated bronchial barrier disruption and regulation by src-family kinase activation
…, E Wilkinson, E Martin, NP Jayasekera, C Blume… - Journal of Allergy and …, 2013 - Elsevier
Background Because TNF-α is increased in severe asthma, we hypothesized that TNF-α
contributes to barrier dysfunction and cell activation in bronchial epithelial cells. We further …
contributes to barrier dysfunction and cell activation in bronchial epithelial cells. We further …
Epithelial function and dysfunction in asthma
Asthma was previously defined as an allergic Th2‐mediated inflammatory immune disorder.
Recently, this paradigm has been challenged because not all pathological changes …
Recently, this paradigm has been challenged because not all pathological changes …