User profiles for Claus Michael-Lehr

Claus-Michael Lehr

Helmholtz Inst. Pharm. Research Saarland (HIPS)
Verified email at helmholtz-hzi.de
Cited by 36760

In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers

CM Lehr, JA Bouwstra, EH Schacht… - International journal of …, 1992 - Elsevier
A number of natural or partially modified polymers was screened for mucoadhesive
properties by routinely measuring the force of detachment for swollen polymer films from pig …

Diverse applications of nanomedicine

B Pelaz, C Alexiou, RA Alvarez-Puebla, F Alves… - ACS …, 2017 - ACS Publications
The design and use of materials in the nanoscale size range for addressing medical and
health-related issues continues to receive increasing interest. Research in nanomedicine …

Nanoparticles–an efficient carrier for drug delivery into the hair follicles

J Lademann, H Richter, A Teichmann, N Otberg… - European Journal of …, 2007 - Elsevier
The penetration and storage behavior of dye-containing nanoparticles (diameter 320nm) into
the hair follicles was investigated. The results were compared to the findings obtained with …

Size-dependent bioadhesion of micro-and nanoparticulate carriers to the inflamed colonic mucosa

A Lamprecht, U Schäfer, CM Lehr - Pharmaceutical research, 2001 - Springer
Purpose. The size-dependent deposition of microparticles and nanoparticles after oral
administration to rats using an experimental model colitis was examined. Local delivery of an …

[HTML][HTML] Towards the sustainable discovery and development of new antibiotics

M Miethke, M Pieroni, T Weber, M Brönstrup… - Nature Reviews …, 2021 - nature.com
An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused
by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to …

Lectin-mediated drug targeting: history and applications

C Bies, CM Lehr, JF Woodley - Advanced drug delivery reviews, 2004 - Elsevier
The purpose of this paper is to review the history of using lectins to target and deliver drugs
to their site of action. The hour of birth of “lectinology” may be defined as the description of …

Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease

ALF Lamprecht, N Ubrich, H Yamamoto… - … of Pharmacology and …, 2001 - ASPET
The use of nanoparticles for targeted oral drug delivery to the inflamed gut tissue in inflammatory
bowel disease was examined. Such a strategy of local drug delivery would be a distinct …

A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro

C Kneuer, M Sameti, U Bakowsky… - Bioconjugate …, 2000 - ACS Publications
Diverse polycationic polymers have been used as nonviral transfection agents. Here we
report the ability of colloidal silica particles with covalently attached cationic surface …

Lectin-mediated drug delivery:: The second generation of bioadhesives

CM Lehr - Journal of Controlled Release, 2000 - Elsevier
This paper reviews some recent developments in the area of bioadhesive drug delivery
systems. The area of bioadhesion in drug delivery had started some 20 years ago by using so-…

Silica nanoparticles modified with aminosilanes as carriers for plasmid DNA

C Kneuer, M Sameti, EG Haltner, T Schiestel… - International journal of …, 2000 - Elsevier
We synthesised silica nanoparticles (SiNP) with covalently linked cationic surface modifications
and demonstrated their ability to electrostatically bind, condense and protect plasmid …