Research and practice in critical care medicine have long been defined by syndromes,
which, despite being clinically recognizable entities, are, in fact, loose amalgams of …

Intensive care unit–acquired weakness (ICUAW) begins within hours of mechanical ventilation
and may not be completely reversible over time. It represents a major functional morbidity …

VEGFs and their receptors have been implicated in the regulation of vascular permeability
in many organ systems, including the lung. Increased permeability and interstitial and …

Rationale: Sepsis refers to the clinical syndrome of severe systemic inflammation precipitated
by infection. Despite appropriate antimicrobial therapy, sepsis-related morbidity and …

Rationale: Patients who developed acute respiratory distress syndrome (ARDS) after
infection with severe respiratory viruses (eg, severe acute respiratory syndrome–coronavirus, …

Objective: To determine the utility of angiopoietin-1 and angiopoietin-2 as potentially novel
biomarkers of morbidity and mortality in patients with severe sepsis. Design: Multicenter …

Long pentraxin 3 (PTX3), an acute-phase protein, is a newly clarified mediator for innate
immunity and inflammation. As a soluble pattern recognition receptor, it has a nonredundant …

Objectives: Coronavirus disease 2019 is caused by the novel severe acute respiratory syndrome
coronavirus 2 virus. Patients admitted to the ICU suffer from microvascular thrombosis, …

In this review, we seek to highlight how critical illness and critical care affect longer-term
outcomes, to underline the contribution of ICU delirium to cognitive dysfunction several months …

▪ Abstract Patients with severe acute respiratory distress syndrome who die usually succumb
to multiorgan failure as opposed to hypoxia. Despite appropriate resuscitation, some …