Sarcoidosis is an enigmatic multisystem disease characterized by the development and
accumulation of granulomas: a compact collection of macrophages that have differentiated into …

Granulomas are lumps of immune cells that can form in various organs. Most granulomas
appear unstructured, yet they have some resemblance to lymphoid organs. To better …

Sarcoidosis is a complex disease characterised by the presence of epithelioid non-caseating
granulomatous inflammation affecting multiple organs and whose aetiology has been …

In this article, early career members of the Assembly 3: Basic and Translational Sciences of
the European Respiratory Society summarise the key messages discussed during six …

Sarcoidosis is an interstitial lung disease (ILD) characterized by interferon-γ (IFN-γ) and T-box
expressed in T cells (TBET) dysregulation. Although one-third of patients progress from …

DC-SIGN + monocyte-derived dendritic cells (mo-DCs) play important roles in bacterial
infections and inflammatory diseases, but the factors regulating their differentiation and …

Background Sarcoidosis (OMIM 181000) is a multi-systemic granulomatous disorder of
unknown origin. Despite multiple genome-wide association (GWAS) studies, no major …

Rationale: Chronic sarcoidosis is a complex granulomatous disease with limited treatment
options that can progress over time. Understanding the molecular pathways contributing to …

Löfgren’s syndrome is an acute form of sarcoidosis that is characterized by the activation of
CD4 + T helper cells. In this issue of JEM, Greaves et al. (2021. J. Exp. Med. https://doi.org/…

Background Sarcoidosis is an inflammatory, granulomatous disease of unknown cause
affecting multiple organs, including the heart. Untreated, unresolved granulomatous …