Serum interleukin 6 is predictive of early functional decline and mortality in interstitial lung disease associated with systemic sclerosis

…, R Hoyles, DM Hansell, NSL Goh, CJ Zappala… - The Journal of …, 2013 - jrheum.org
Objective. Biomarkers of progression of interstitial lung disease (ILD) are needed to allow
early therapeutic intervention in patients with scleroderma-associated disease (SSc-ILD). …

Baseline characteristics of idiopathic pulmonary fibrosis: analysis from the Australian Idiopathic Pulmonary Fibrosis Registry

…, S Chapman, EH Walters, C Zappala… - European …, 2017 - Eur Respiratory Soc
The prevalence of idiopathic pulmonary fibrosis (IPF), a fatal and progressive lung disease,
is estimated at 1.25–63 out of 100 000, making large population studies difficult. Recently, …

Health‐related quality of life in idiopathic pulmonary fibrosis: Data from the A ustralian IPF R egistry

…, E Paul, PN Reynolds, EH Walters, CJ Zappala… - …, 2017 - Wiley Online Library
Background and objective Studies analysing the effect of worsening pulmonary physiological
impairment in idiopathic pulmonary fibrosis ( IPF ) with respect to quality of life have been …

Predicting pulmonary fibrosis disease course from past trends in pulmonary function

SL Schmidt, N Tayob, MK Han, C Zappala, D Kervitsky… - Chest, 2014 - Elsevier
Background The clinical course of idiopathic pulmonary fibrosis (IPF) is characterized by
progressive decline in lung function and eventual mortality. We sought to determine if future …

A composite serum biomarker index for the diagnosis of systemic sclerosis–associated interstitial lung disease: a multicenter, observational cohort study

…, PN Reynolds, D Tan, CJ Zappala… - Arthritis & …, 2023 - Wiley Online Library
Objective In patients with systemic sclerosis (SSc), we investigated composite serum biomarker
panels for the diagnosis and risk stratification of SSc–associated interstitial lung disease (…

Deep learning–based outcome prediction in progressive fibrotic lung disease using high-resolution computed tomography

…, Y Moodley, PN Reynolds, C Zappala… - American journal of …, 2022 - atsjournals.org
Rationale: Reliable outcome prediction in patients with fibrotic lung disease using baseline
high-resolution computed tomography (HRCT) data remains challenging. Objectives: To …

[HTML][HTML] Disease progression in idiopathic pulmonary fibrosis with mild physiological impairment: analysis from the Australian IPF registry

…, P Reynolds, E Haydn Walters, C Zappala… - BMC pulmonary …, 2018 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal fibrosing lung
disease of unknown cause. The advent of anti-fibrotic medications known to slow disease …

Biomarker signatures for progressive idiopathic pulmonary fibrosis

…, PN Reynolds, S Chapman, C Zappala… - European …, 2022 - Eur Respiratory Soc
Background Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease in which
circulatory biomarkers have the potential for guiding management in clinical practice. We …

[HTML][HTML] Gastroesophageal reflux and antacid therapy in IPF: analysis from the Australia IPF Registry

…, S Chapman, EH Walters, C Zappala… - BMC pulmonary …, 2019 - Springer
Background and objective Gastroesophageal reflux disease (GORD) is highly prevalent in
idiopathic pulmonary fibrosis (IPF) and may play a role in its pathogenesis. Recent IPF …

Determinants and outcomes of prolonged anxiety and depression in idiopathic pulmonary fibrosis

…, CJ Ryerson, EH Walters, CJ Zappala… - European …, 2017 - Eur Respiratory Soc
We have recently shown that anxiety and depression are common comorbidities for people
with interstitial lung disease (ILD). In a cross-sectional single-centre study, the prevalence of …