Objective The 1980 American College of Rheumatology (ACR) classification criteria for
systemic sclerosis (SSc) lack sensitivity for early SSc and limited cutaneous SSc. The present …

The aim of a clinical classification of pulmonary hypertension (PH) is to group together different
manifestations of disease sharing similarities in pathophysiologic mechanisms, clinical …

Since the 1st World Symposium on Pulmonary Hypertension (WSPH) in 1973, pulmonary
hypertension (PH) has been arbitrarily defined as mean pulmonary arterial pressure (mPAP) ≥…

Systemic sclerosis, also called scleroderma, is an immune-mediated rheumatic disease that
is characterised by fibrosis of the skin and internal organs and vasculopathy. Although …

Rationale: In interstitial lung disease complicating systemic sclerosis (SSc-ILD), the optimal
prognostic use of baseline pulmonary function tests (PFTs) and high-resolution computed …

Background A phase 2 trial of tocilizumab showed preliminary evidence of efficacy in systemic
sclerosis. We assessed skin fibrosis and systemic sclerosis-associated interstitial lung …

The aim was to update the 2009 European League against Rheumatism (EULAR)
recommendations for the treatment of systemic sclerosis (SSc), with attention to new therapeutic …

Objective The lack of randomized controlled trials (RCTs) in pulmonary fibrosis in systemic
sclerosis (SSc) has hampered an evidence‐based approach to treatment. This RCT was …

Understanding the origins and roles of cardiac progenitor cells is important for elucidating
the pathogenesis of congenital and acquired heart diseases 1 , 2 . Moreover, manipulation of …

Objective Earlier detection of pulmonary arterial hypertension (PAH), a leading cause of death
in systemic sclerosis (SSc), facilitates earlier treatment. The objective of this study was to …