Clinical and translational research has played a major role in advancing our understanding
of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms …

This review summarizes an expanding body of knowledge indicating that failure to resolve
inflammation and altered immune processes underlie the development of pulmonary arterial …

Knowledge of the pathobiology of pulmonary hypertension (PH) continues to accelerate.
However, fundamental gaps remain in our understanding of the underlying pathological …

Background— The French pulmonary hypertension (PH) registry allows the survey of
epidemiological trends. Isolated cases of precapillary PH have been reported in patients who have …

Coronavirus disease 2019 (COVID-19) represents a public health crisis of pandemic
proportions. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the …

Loss-of-function mutations in bone morphogenetic protein receptor II (BMP-RII) are linked to
pulmonary arterial hypertension (PAH); the ligand for BMP-RII, BMP-2, is a negative …

Background— The role of right ventricular (RV) diastolic stiffness in pulmonary arterial
hypertension (PAH) is not well established. Therefore, we investigated the presence and possible …

Background— The mechanism of pulmonary artery smooth muscle cell (PA-SMC)
hyperplasia in idiopathic pulmonary artery hypertension (iPH) may involve both an inherent …

Rationale: Patients with idiopathic pulmonary arterial hypertension (iPAH) often have a low
cardiac output. To compensate, neurohormonal systems such as the renin–angiotensin–…

Pulmonary arterial remodeling characterized by increased vascular smooth muscle density
is a common lesion seen in pulmonary arterial hypertension (PAH), a deadly condition. …