[HTML][HTML] Analysis of the IGF-system in milk from farm animals–Occurrence, regulation, and biomarker potential

…, E Wirthgen, S Olm, HM Hammon, A Hoeflich - Growth Hormone & IGF …, 2017 - Elsevier
IGFs and IGF-binding proteins (IGFBPs) are abundantly present in milk and in dairy products.
Compared to the IGFs, the IGFBP have received less attention in milk, although truncated …

Diffusion barrier properties of TiW between Si and Cu

SQ Wang, S Suthar, C Hoeflich, BJ Burrow - Journal of applied physics, 1993 - pubs.aip.org
100‐nm‐thick TiW (30 at. % Ti) films were used as diffusion barriers between silicon
substrates and thin Cu films. Sheet resistance measurements, Rutherford backscattering …

[HTML][HTML] Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential in vivo

…, H Schaffhauser, C Hoeflich, A Hoeflich… - … Therapy-Nucleic Acids, 2023 - cell.com
Insulin-like growth factor I (IGF-I) is a growth-promoting anabolic hormone that fosters cell
growth and tissue homeostasis. IGF-I deficiency is associated with several diseases, including …

[HTML][HTML] Increased concentrations of insulin-like growth factor binding protein (IGFBP)-2, IGFBP-3, and IGFBP-4 are associated with fetal mortality in pregnant cows

…, S Peter, M Jung, C Höflich, A Hoeflich… - Frontiers in …, 2018 - frontiersin.org
Insulin-like growth factors (IGFs) play a critical role in fetal growth, and components of the IGF
system have been associated with fetal growth restriction in women. In human pregnancy, …

[HTML][HTML] Quantitative Western ligand blotting reveals common patterns and differential features of IGFBP-fingerprints in domestic ruminant breeds and species

…, B Brand, J Langbein, F Metzger, A Hoeflich - Growth Hormone & IGF …, 2016 - Elsevier
The insulin-like growth factor binding proteins (IGFBPs) are determinants of local IGF-effects
and thus have an impact on growth and metabolism in vertebrate species. In farm animals, …

[HTML][HTML] Interference of stress with the somatotropic axis in pigs–lights on new biomarkers

…, S Erdmann, K Schluricke, L Faucitano, A Hoeflich - Scientific reports, 2017 - nature.com
The acceptance of animal products is increasingly associated with standardized animal
welfare, which relates to appropriate animal husbandry from birth to slaughter. In particular, …

[HTML][HTML] Overlap of peak growth activity and peak IGF-1 to IGFBP ratio: delayed increase of IGFBPs versus IGF-1 in serum as a mechanism to speed up and down …

…, M Langhammer, F Metzger, C Höflich, A Hoeflich - Cells, 2020 - mdpi.com
Forced expression of insulin-like growth factor binding proteins (IGFBPs) in transgenic mice
has clearly revealed inhibitory effects on somatic growth. However, by this approach, it …

[HTML][HTML] Effect of IGFBP-4 during In Vitro Maturation on Developmental Competence of Bovine Cumulus Oocyte Complexes

…, JC Gutiérrez-Añez, C Hoeflich, A Hoeflich… - Animals, 2024 - mdpi.com
Simple Summary Insulin-like growth factors improve oocyte quality and are necessary for
oocyte maturation. However, their effectiveness is contingent upon regulated availability, …

[HTML][HTML] Development of a sensitive bioassay for the analysis of IGF-related activation of AKT/mTOR signaling in biological matrices

…, UK Zettl, S Holtze, TB Hildebrandt, E Wolf, A Hoeflich - Cells, 2021 - mdpi.com
The bioactivity of the IGF system is not a function of isolated hormone concentrations in a given
biological matrix. Instead, the biological activities of IGFs are regulated by IGFBPs, IGFBP …

Circulating insulin‐like growth factor‐related biomarkers: Correlates and responses to calcium supplementation in colorectal adenoma patients

…, V Fedirko, WD Flanders, C Höflich… - Molecular …, 2017 - Wiley Online Library
Circulating insulin‐like growth factor 1 (IGF‐1) may be directly associated with colorectal
cancer risk, and IGF binding protein 3 (IGFBP‐3) is one of the most abundantly expressed …