TERT Promoter Mutations in Familial and Sporadic Melanoma

S Horn, A Figl, PS Rachakonda, C Fischer, A Sucker… - Science, 2013 - science.org
Cutaneous melanoma occurs in both familial and sporadic forms. We investigated a
melanoma-prone family through linkage analysis and high-throughput sequencing and identified a …

Early experience alters brain function and structure

…, PS Huppi, SC Butler, N Conneman, C Fischer… - …, 2004 - publications.aap.org
Objective. To investigate the effects of early experience on brain function and structure. Methods.
A randomized clinical trial tested the neurodevelopmental effectiveness of the Newborn …

Comprehensive analysis of thiopurine S-methyltransferase phenotype–genotype correlation in a large population of German-Caucasians and identification of novel …

E Schaeffeler, C Fischer, D Brockmeier… - Pharmacogenetics …, 2004 - journals.lww.com
The thiopurine S-methyltransferase (TPMT) genetic polymorphism has a significant clinical
impact on the toxicity of thiopurine drugs. It has been proposed that the identification of …

Non-random radial higher-order chromatin arrangements in nuclei of diploid human cells

…, T Volm, A Brero, G Kreth, J Walter, C Fischer… - Chromosome …, 2001 - Springer
A quantitative comparison of higher-order chromatin arrangements was performed in human
cell types with three-dimensionally (3D) preserved, differently shaped nuclei. These cell …

[HTML][HTML] Biodiversity effects on ecosystem functioning in a 15-year grassland experiment: Patterns, mechanisms, and open questions

…, F Buscot, C Engels, C Fischer, M Fischer… - Basic and applied …, 2017 - Elsevier
In the past two decades, a large number of studies have investigated the relationship
between biodiversity and ecosystem functioning, most of which focussed on a limited set of …

Carnosine as a Protective Factor in Diabetic Nephropathy: Association With a Leucine Repeat of the Carnosinase Gene CNDP1

…, P Brinkkoetter, V Peters, N Rind, C Fischer… - Diabetes, 2005 - Am Diabetes Assoc
The risk of diabetic nephropathy is partially genetically determined. Diabetic nephropathy is
linked to a gene locus on chromosome 18q22.3-q23. We aimed to identify the causative …

Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism

…, E Schäffeler, C Marx, C Fischer… - Pharmacogenetics …, 2002 - journals.lww.com
The efficacy of the immunosuppressants azathioprine and 6-mercaptopurine has been well
established in the therapy of inflammatory bowel diseases (IBD). However, its use has been …

Safety and efficacy of exercise training in various forms of pulmonary hypertension

…, G Staehler, M Halank, C Fischer… - European …, 2012 - Eur Respiratory Soc
The objective of this prospective study was to assess safety and efficacy of exercise training
in a large cohort of patients with different forms and World Health Organization (WHO) …

Exercise training improves peak oxygen consumption and haemodynamics in patients with severe pulmonary arterial hypertension and inoperable chronic thrombo …

…, H Klose, J Weidenhammer, C Fischer… - European heart …, 2016 - academic.oup.com
Aims The impact of exercise training on the right heart and pulmonary circulation has not yet
been invasively assessed in patients with pulmonary hypertension (PH) and right heart …

Therapeutic efficacy of sulfasalazine and its metabolites in patients with ulcerative colitis and Crohn's disease

U Klotz, K Maier, C Fischer… - New England Journal of …, 1980 - Mass Medical Soc
We studied the therapeutic efficacy of sulfasalazine and its metabolites sulfapyridine and 5-aminosalicylic
acid in nine patients with Crohn's disease and in 23 patients with ulcerative …