[PDF][PDF] Severe COVID-19 is marked by a dysregulated myeloid cell compartment

…, J Raabe, KM Kaiser, MT Vinh, G Rieke, C Meisel… - Cell, 2020 - cell.com
Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however,
a subset of patients progress to severe disease and respiratory failure. The mechanism …

[HTML][HTML] Central nervous system injury-induced immune deficiency syndrome

C Meisel, JM Schwab, K Prass, A Meisel… - Nature Reviews …, 2005 - nature.com
Infections are a leading cause of morbidity and mortality in patients with acute CNS injury. It
has recently become clear that CNS injury significantly increases susceptibility to infection …

[HTML][HTML] The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

…, A de la Fuente, I Martin-Loeches, C Meisel… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1 …

K Prass, C Meisel, C Höflich, J Braun… - The Journal of …, 2003 - rupress.org
Infections are a leading cause of death in stroke patients. In a mouse model of focal cerebral
ischemia, we tested the hypothesis that a stroke-induced immunodeficiency increases the …

Frequency of single nucleotide polymorphisms in the P‐glycoprotein drug transporter MDR1 gene in white subjects

I Cascorbi, T Gerloff, A Johne, C Meisel… - Clinical …, 2001 - Wiley Online Library
Background P‐glycoprotein, the gene product of MDR1, confers multidrug resistance against
antineoplastic agents but also plays an important role in the bioavailability of common …

Granulocyte–macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial

C Meisel, JC Schefold, R Pschowski… - American journal of …, 2009 - atsjournals.org
Christian MeiselChristian Meisel … Docke WD, Hoflich C, Davis KA, Rottgers K, Meisel
C, Kiefer P, Weber SU, Hedwig-Geissing M, Kreuzfelder E, Tschentscher P, et al. Monitoring …

Stroke-induced immunodepression: experimental evidence and clinical relevance

…, H Harms, C Meisel, T Ziemssen, K Prass, A Meisel - Stroke, 2007 - Am Heart Assoc
Stroke affects the normally well-balanced interplay of the 2 supersystems: the nervous and
the immune system. Recent research elucidated some of the involved signals and …

Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta.

F Randow, U Syrbe, C Meisel, D Krausch… - The Journal of …, 1995 - rupress.org
Tolerance of monocytes/macrophages to endotoxin (lipopolysaccharide [LPS]) can be induced
both in vivo and in vitro by LPS itself. Exposure to LPS, even at a very low dose, induces …

Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2–mediated lung mucosal immune responses

…, S Lehar, S Lin, L Poisson, C Meisel… - The Journal of …, 1999 - rupress.org
T1/ST2 is an orphan receptor of unknown function that is expressed on the surface of murine
T helper cell type 2 (Th2), but not Th1 effector cells. In vitro blockade of T1/ST2 signaling …

Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome

…, C Rödelsperger, C Marcelis, U Kölsch, C Meisel… - Nature …, 2010 - nature.com
Hyperphosphatasia mental retardation (HPMR) syndrome is an autosomal recessive form of
mental retardation with distinct facial features and elevated serum alkaline phosphatase. …