Progression of lung disease in preschool patients with cystic fibrosis

…, R Jensen, ME Pizarro, M Kane, CC Clem… - American journal of …, 2017 - atsjournals.org
Rationale: Implementation of intervention strategies to prevent lung damage in early cystic
fibrosis (CF) requires objective outcome measures that capture and track lung disease. …

Bronchopulmonary dysplasia and perinatal characteristics predict 1-year respiratory outcomes in newborns born at extremely low gestational age: a prospective …

…, K Ciccio, CM Cotten, K Fisher, J Sharp, C Clem… - The Journal of …, 2017 - Elsevier
Objective To assess the utility of clinical predictors of persistent respiratory morbidity in
extremely low gestational age newborns (ELGANs). Study design We enrolled ELGANs (<29 …

Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial

…, N Schaap, M Davis, S Davis, C Clem… - The lancet Respiratory …, 2019 - thelancet.com
Background Inhaled hypertonic saline enhances mucociliary clearance, improves lung
function, and reduces pulmonary exacerbations in people with cystic fibrosis older than age 6 …

The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled …

…, Y Belessis, M Bonte, J Cheney, C Clem… - The lancet Respiratory …, 2022 - thelancet.com
Background In the Saline Hypertonic in Preschoolers (SHIP) study, inhaled 7% hypertonic
saline improved the lung clearance index in children aged 3–6 years with cystic fibrosis, but it …

Lung clearance index to track acute respiratory events in school-age children with cystic fibrosis

…, N McDonald, SM Isaac, M Davis, C Clem… - American Journal of …, 2021 - atsjournals.org
Rationale: The lung clearance index (LCI) is responsive to acute respiratory events in
preschool children with cystic fibrosis (CF), but its utility to identify and manage these events in …

Determinants of lung disease progression measured by lung clearance index in children with cystic fibrosis

…, M Davis, R Jensen, CC Clem… - European …, 2021 - Eur Respiratory Soc
The lung clearance index (LCI) measured by the multiple breath washout (MBW) test is
sensitive to early lung disease in children with cystic fibrosis. While LCI worsens during the …

Multiple-breath washout outcomes are sensitive to inflammation and infection in children with cystic fibrosis

…, J Grdosic, A Harper, B Skoric, C Clem… - Annals of the …, 2017 - atsjournals.org
Rationale: The lung clearance index is a measure of ventilation distribution derived from the
multiple-breath washout technique. The lung clearance index is increased in the presence …

Respiratory medications in infants< 29 weeks during the first year postdischarge: the Prematurity and Respiratory Outcomes Program (PROP) consortium

…, E Popplewell, S Prentice, K Ciccio, C Clem… - The Journal of …, 2019 - Elsevier
… , and the lead respiratory therapy coordinator, Charles Clem, RRT, at Indiana University.
The PROP logo was designed by Dr Rita Dadiz (Rochester). We also acknowledge Carol J. …

Comparison of multiple breath washout and spirometry in children with primary ciliary dyskinesia and cystic fibrosis and healthy controls

…, E Sullivan, M Siegel, I Bauer, C Clem… - Annals of the …, 2020 - atsjournals.org
Rationale: In cystic fibrosis (CF), the lung clearance index (LCI), derived from multiple breath
washout (MBW), is more sensitive in detecting early lung disease than FEV 1 ; MBW has …

Pulmonary function tests in extremely low gestational age infants at one year of age

…, E Eichenwald, H Panitch, C Clem… - Pediatric …, 2022 - Wiley Online Library
Rationale Identifying neonatal and post‐discharge exposures among extremely low gestational
age newborns (ELGANs) that drive increased pulmonary morbidity and abnormal lung …