Background The level of staffing in hospitals is often lower on weekends than on weekdays,
despite a presumably consistent day-to-day burden of disease. It is uncertain whether in-…

Background This study evaluated the risk of long-term analgesic use after low-risk surgery
in older adults not previously prescribed analgesics. Methods We conducted a retrospective …

Background: Antipsychotic drugs are widely used to manage behavioral and psychological
symptoms in dementia despite concerns about their safety. Objective: To examine the …

Background Previous studies of hospital readmission have focused on specific conditions
or populations and generated complex prediction models. Objective To identify predictors of …

Objective To investigate if published studies tend to report favourable cost effectiveness ratios
(below $20 000, $50 000, and $100 000 per quality adjusted life year (QALY) gained) and …

Background Cholinesterase inhibitors are commonly prescribed to treat dementia, but their
adverse effect profile has received little attention. These drugs can provoke symptomatic …

Context Patients discharged from acute care hospitals may be at risk for unintentional
discontinuation of medications prescribed for chronic diseases. The intensive care unit (ICU) may …

BACKGROUND: Sodium polystyrene sulfonate (Kayexalate; Sanofi-Aventis, Paris, France)
is a cation-exchange resin routinely used in the management of hyperkalemia. However, its …

Background Antipsychotic therapy is widely used to treat behavioral problems in older adults
with dementia. Cohort studies evaluating the safety of antipsychotic therapy generally focus …

Survivors of severe acute kidney injury remain at high risk of death well after apparent
recovery from the initial insult. Here we determine whether early nephrology follow-up after a …