Skeletal muscle atrophy commonly occurs in acute and chronic disease. The expression of
the muscle-specific E3 ligases atrogin-1 (MAFbx) and muscle RING finger 1 (MuRF1) is …

… Op den Kamp, Céline M; Langen, Ramon C; Haegens, Astrid; Schols, Annemie M … Articles
in PubMed by Céline M Op den Kamp … Other articles in this journal by Céline M Op den Kamp …

Background Cachexia, highly prevalent in patients with non‐small cell lung cancer (NSCLC),
impairs quality of life and is associated with reduced tolerance and responsiveness to …

Background: Experimental models of cancer cachexia have indicated that systemic
inflammation induces muscle-protein breakdown and wasting via muscular nuclear transcription …

Background Cachexia augments cancer‐related mortality and has devastating effects on
quality of life. Pre‐clinical studies indicate that systemic inflammation‐induced loss of muscle …

Background and purpose Radiation‐esophagitis and weight loss are fre.uently observed
toxicities in patients treated with concurrent chemo‐radiotherapy (CT‐RT) for non‐small cell …

… Gosker PhD , Bram van den Borst PhD, MD , Celine M. Op den Kamp PhD, MD , Ilse GM Slot
PhD , Annemie MWJ Schols PhD … CM Op den Kamp, RC Langen, FJ Snepvangers, et al. …

Rationale Experimental research has indicated that increased muscular Nuclear Factor
kappa B (NF-kB) and subsequent ubiquitin (Ub) proteasome system (UPS) activity plays a …

Background Quadriceps muscle in COPD is characterized by a loss of oxidative phenotype
which adversely affects exercise performance. We recently showed in a large cohort of …

Cachexia has devastating effects on quality of life and augments cancer-related mortality.
Preclinical studies indicate that systemic inflammation-induced loss of muscle oxidative …