Background Genetic differences in immune responses may affect susceptibility to mycobacterial
infection, but no specific genes have been implicated in humans. We studied four …

We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone,
induced human and mouse naive CD4 + T cells to differentiate in vitro into regulatory T …

We previously reported that human CD4 + Tregs secrete high levels of IL-10 when stimulated
in the presence of dexamethasone and calcitriol (vitamin D3). We now show that following …

Interleukin‐10 (IL‐10) is a cytokine with broad anti‐inflammatory properties by its suppression
of both macrophage and dendritic cell function, including antigen‐presenting cell function …

Asthma is characterized by T helper cell 2 (Th2) type inflammation, leading to airway
hyperresponsiveness and tissue remodeling. Th2 cell-driven inflammation is likely to represent an …

A well-functioning immune system is vital for a healthy body. Inadequate and excessive
immune responses underlie diverse pathologies such as serious infections, metastatic …

Importance Asthma and wheezing begin early in life, and prenatal vitamin D deficiency has
been variably associated with these disorders in offspring. Objective To determine whether …

Rationale: Little is known about vitamin D status and its effect on asthma pathophysiology in
children with severe, therapy-resistant asthma (STRA). Objectives: Relationships between …

Background There remains uncertainty about the impact of menopausal hormone therapy (MHT)
on women’s health. A systematic, comprehensive assessment of the effects on multiple …

The mode of action of Leflunomide, an immunomodulatory drug used in rheumatoid arthritis,
is debated. This study, using 14 C-labeled de novo purine and pyrimidine synthesis …