Background Chronic obstructive pulmonary disease (COPD) is thought to result from an
accelerated decline in forced expiratory volume in 1 second (FEV 1 ) over time. Yet it is possible …

Leukocyte-derived proteinases have the capacity to degrade every component of the extracellular
matrix, and thereby play fundamental roles in physiological processes. However, if the …

The pathogenesis of chronic obstructive pulmonary disease (COPD) remains unclear, but
involves loss of alveolar surface area (emphysema) and airway inflammation (bronchitis) as …

Serine proteinases of human polymorphonuclear neutrophils play an important role in
neutrophil-mediated proteolytic events; however, the non-oxidative mechanisms by which the …

Drug survival reflects a drug’s effectiveness, safety, and tolerability. We assessed the drug
survival of biologics used to treat psoriasis in a prospective national pharmacovigilance …

Idiopathic pulmonary fibrosis (IPF) is a restrictive lung disease that is associated with high
morbidity and mortality. Current medical therapies are not fully effective at limiting mortality in …

Increased numbers of T lymphocytes are observed in the lungs of patients with chronic
obstructive pulmonary disease, but their role in the disease process is not known. We …

Chronic obstructive pulmonary disease (COPD) involves aberrant airway inflammatory
responses to cigarette smoke (CS) that are associated with epithelial cell dysfunction, cilia …

Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but
other determinants of the disease are incompletely understood. Clonal hematopoiesis of …

Little is known about the cell biology or the biologic roles of polymorphonuclear cell (PMN)-derived
matrix metalloproteinase-8 (MMP-8). When activated with proinflammatory mediators, …