Six shades of vascular smooth muscle cells illuminated by KLF4 (Krüppel-Like Factor 4)
…, CJM de Vries, D Micha, V de Waard - … , and vascular biology, 2021 - Am Heart Assoc
Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels forming
the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to contract …
the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to contract …
[HTML][HTML] NR4A nuclear receptors are orphans but not lonesome
…, DS Koenis, CM van Tiel, CJM de Vries - Biochimica et Biophysica …, 2014 - Elsevier
The NR4A subfamily of nuclear receptors consists of three mammalian members: Nur77,
Nurr1, and NOR-1. The NR4A receptors are involved in essential physiological processes such …
Nurr1, and NOR-1. The NR4A receptors are involved in essential physiological processes such …
Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes
…, YW Elderkamp, J Seppen, CJM De Vries… - The American journal of …, 2005 - Elsevier
Lung Krüppel-like factor (LKLF/KLF2) is an endothelial transcription factor that is crucially
involved in murine vasculogenesis and is specifically regulated by flow in vitro. We now show …
involved in murine vasculogenesis and is specifically regulated by flow in vitro. We now show …
Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages
…, MJHM Jacobs, JMFG Aerts, CJM de Vries - … , and vascular biology, 1999 - Am Heart Assoc
Atherosclerosis is initiated by the infiltration of monocytes into the subendothelial space of
the vessel wall and subsequent lipid accumulation of the activated macrophages. The …
the vessel wall and subsequent lipid accumulation of the activated macrophages. The …
[HTML][HTML] Protein–protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular disease
…, K Kurakula, DS Koenis, CJM de Vries - Biochimica et Biophysica …, 2016 - Elsevier
FHL2 belongs to the LIM-domain only proteins and contains four and a half LIM domains,
each of which are composed of two zinc finger structures. FHL2 exhibits specific interaction …
each of which are composed of two zinc finger structures. FHL2 exhibits specific interaction …
Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses
…, H Pannekoek, CJM De Vries - … , and vascular biology, 2006 - Am Heart Assoc
Objective— Atherosclerosis is an inflammatory disease in which macrophage activation and
lipid loading play a crucial role. In this study, we investigated expression and function of the …
lipid loading play a crucial role. In this study, we investigated expression and function of the …
Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors
JP de Winter, P ten Dijke, CJM de Vries… - Molecular and cellular …, 1996 - Elsevier
Follistatin is an activin-binding protein, which inhibits activin bioactivity in several biological
systems. In the present study it is demonstrated that preincubation of iodinated activin A with …
systems. In the present study it is demonstrated that preincubation of iodinated activin A with …
Protective function of transcription factor TR3 orphan receptor in atherogenesis: decreased lesion formation in carotid artery ligation model in TR3 transgenic mice
…, B Pichon, H Pannekoek, CJM de Vries - Circulation, 2002 - Am Heart Assoc
Background— Smooth muscle cells (SMCs) play a key role in intimal thickening in atherosclerosis
and restenosis. The precise signaling pathways by which the proliferation of SMCs is …
and restenosis. The precise signaling pathways by which the proliferation of SMCs is …
Bone marrow–specific deficiency of nuclear receptor Nur77 enhances atherosclerosis
…, MJJ Gijbels, V De Waard, CJM De Vries - Circulation …, 2012 - Am Heart Assoc
Rationale: Nuclear receptor Nur77, also known as NR4A1, TR3, or NGFI-B, is expressed in
human atherosclerotic lesions in macrophages, endothelial cells, T cells and smooth muscle …
human atherosclerotic lesions in macrophages, endothelial cells, T cells and smooth muscle …
Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions
Macrophages are key immune cells found in atherosclerotic plaques and critically shape
atherosclerotic disease development. Targeting the functional repertoire of macrophages may …
atherosclerotic disease development. Targeting the functional repertoire of macrophages may …