Objective To guide nosology and classification of patients with eosinophilic granulomatosis
with polyangiitis (EGPA) based on phenotype and presence or absence of ANCA. Methods …

Asthma is a chronic inflammatory disorder of the airways that leads to acute symptoms,
exacerbations and sometimes, for a small part of the asthmatic population, fatal or near-fatal …

The understanding of EGPA continues to advance, but many gaps in knowledge remain. The
nomenclature remains a source of conceptual variance in terms of demonstrated presence …

We investigated a possible beneficial role for bilirubin, one of the products of heme
degradation by the cytoprotective enzyme heme oxygenase‐1 in counteracting Escherichia coli …

Omalizumab is a monoclonal anti-IgE antibody used to treat severe allergic asthma (SAA).
The aim of the STELLAIR study was to determine the importance of pre-treatment blood …

Carbon monoxide (CO), one of the end products of heme oxygenase activity,inhibits smooth
muscle proliferation by decreasing ERK1/2 phosphorylation andcyclin D1 expression, a …

Background While up to 50% of patients with severe asthma have no evidence of allergy,
IgE has been linked to asthma, irrespective of atopic status. Omalizumab, an anti-IgE …

Background ANDHI was done to assess the efficacy of benralizumab, including onset of effect
and impact on health-related quality of life (HRQOL), exacerbation rate, lung function, and …

… PhD d ∗ , Gabriel Thabut MD, PhD a b c d e g , Marie-Christine Dombret MD a b c f g ,
Dominique Knapp MS a b c g , Fatima Hamidi MS a b c , Loubna Alavoine MD h , Camille Taillé …

This study investigated whether inducible HO-1 is targeted to mitochondria and its putative
effects on oxidative metabolism in rat liver. Western blot and immune-electron microscopy in …