Currently available inhaled bronchodilators used as therapy for chronic obstructive pulmonary
disease (COPD) necessitate multiple daily dosing. The present study evaluates the long-…

Tiotropium (Spiriva; Ba679BR) is a new-generation, long-acting anticholinergic bronchodilator
that has muscarinic M 1 and M 3 receptor subtype selectivity. A multicenter, randomized, …

… MD, FCCP 3 , Serby Charles W. MD 4 , Menjoge Shailendra S. PhD 4 , Witek Theodore J. …
TJ Witek, JF Souhrada, CW Serby, et al. … S Chodosh, J Flanders, CW Serby, et al. …

Study objective To conduct a post hocpharmacoeconomic evaluation of two double-blind,
randomized, prospective, parallel group studies comparing the long-term efficacy and safety of …

The HandiHaler ® is a dry powder breath activated inhaler system developed for inhalation
therapy for patients with airway disease. Its operation is based on the evacuation of powder …

Objective Bronchodilators are routinely used in the long-term therapy of patients with COPD.
These drugs are generally evaluated for their short-term bronchodilatory effects. Long-term …

Study objectives To determine whether the combination of ipratropium bromide and albuterol
results in greater and more consistent pulmonary function test (PFT) response rates than …

PURPOSE: Compliance with inhaled medication prescribed for multiple scheduled doses
each day is generally regarded as unsatisfactory. Tiotropium (TIO) is a long acting inhaled …

The effectiveness of inhaled versus oral metaproterenol in preventing exercise‐induced asthma
(EIA) was studied. Inhaled metaproterenol given 10 min before the exercise significantly …

Results The mean baseline FEV 1-values were very similar on the three test days (2.93 L±1.0
SD, 2.99 L±1.0 SD, and 3.02 L±1.1 SD for placebo, fenoterol 0.4 mg and fenoterol 0.8 mg, …