Synthetic receptors
JH Hartley, TD James, CJ Ward - Journal of the Chemical Society …, 2000 - pubs.rsc.org
… Wärnmark and co-workers have employed a condensation reaction to synthesise the C 2
symmetric bis(18-crown-6) analogue 1, which binds heptane-1,7-diylbis(ammonium chloride) …
symmetric bis(18-crown-6) analogue 1, which binds heptane-1,7-diylbis(ammonium chloride) …
Spectrum of the Mutations in B ernard–S oulier Syndrome
…, A Pecci, P Noris, A Srivastava, C Ward… - Human …, 2014 - Wiley Online Library
Bernard–Soulier syndrome ( BSS ) is a rare autosomal recessive bleeding disorder
characterized by defects of the GPIb‐IX‐V complex, a platelet receptor for von Willebrand factor ( …
characterized by defects of the GPIb‐IX‐V complex, a platelet receptor for von Willebrand factor ( …
Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets
Cystic fibrosis (CF) is a life-limiting disease characterised by recurrent respiratory infections,
inflammation and lung damage. The volume and composition of the airway surface liquid (…
inflammation and lung damage. The volume and composition of the airway surface liquid (…
The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains
Abstract Characterization of the polycystic kidney disease 1 (PKD1) gene has been complicated
by genomic rearrangements on chromosome 16. We have used an exon linking strategy…
by genomic rearrangements on chromosome 16. We have used an exon linking strategy…
The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein
… ; and 10 min at 72 C. We generated heteroduplexes by treating the PCR product as follows:
… 95 C; cooling to 65 C at 0.1 C/s; 30 min at 65 C; cooling to 37 C at 0.1 C/s; and 10 min at 37 C…
… 95 C; cooling to 65 C at 0.1 C/s; 30 min at 65 C; cooling to 37 C at 0.1 C/s; and 10 min at 37 C…
Angiotensin II type 1 receptor blockade attenuates TGF-β–induced failure of muscle regeneration in multiple myopathic states
Skeletal muscle has the ability to achieve rapid repair in response to injury or disease 1 . Many
individuals with Marfan syndrome (MFS), caused by a deficiency of extracellular fibrillin-1…
individuals with Marfan syndrome (MFS), caused by a deficiency of extracellular fibrillin-1…
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection
C Goujon, O Moncorgé, H Bauby, T Doyle, CC Ward… - Nature, 2013 - nature.com
Animal cells harbour multiple innate effector mechanisms that inhibit virus replication. For the
pathogenic retrovirus human immunodeficiency virus type 1 (HIV-1), these include widely …
pathogenic retrovirus human immunodeficiency virus type 1 (HIV-1), these include widely …
[PDF][PDF] Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria
One cause of amyotrophic lateral sclerosis (ALS) is mutation in ubiquitously expressed
copper/zinc superoxide dismutase (SOD1), but the mechanism of toxicity to motor neurons is …
copper/zinc superoxide dismutase (SOD1), but the mechanism of toxicity to motor neurons is …
[HTML][HTML] Chronic phospholamban–sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy
S Minamisawa, M Hoshijima, G Chu, CA Ward, K Frank… - Cell, 1999 - cell.com
Dilated cardiomyopathy and end-stage heart failure result in multiple defects in cardiac
excitation–contraction coupling. Via complementation of a genetically based mouse model of …
excitation–contraction coupling. Via complementation of a genetically based mouse model of …
X-ROS signaling: rapid mechano-chemo transduction in heart
We report that in heart cells, physiologic stretch rapidly activates reduced-form nicotinamide
adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) to produce reactive oxygen …
adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) to produce reactive oxygen …