Progress and problems with the use of viral vectors for gene therapy
CE Thomas, A Ehrhardt, MA Kay - Nature Reviews Genetics, 2003 - nature.com
Gene therapy has a history of controversy. Encouraging results are starting to emerge from
the clinic, but questions are still being asked about the safety of this new molecular medicine. …
the clinic, but questions are still being asked about the safety of this new molecular medicine. …
Mechanisms of, and barriers to, horizontal gene transfer between bacteria
CM Thomas, KM Nielsen - Nature reviews microbiology, 2005 - nature.com
Mutation and horizontal gene transfer (HGT) continually give rise to new bacterial genotypes.
Infrequently, such new bacterial genotypes establish and spread in the larger population …
Infrequently, such new bacterial genotypes establish and spread in the larger population …
The Parkinson progression marker initiative (PPMI)
…, S Frank, CA Thomas, I Richard, C Deeley… - Progress in …, 2011 - Elsevier
The Parkinson Progression Marker Initiative (PPMI) is a comprehensive observational,
international, multi-center study designed to identify PD progression biomarkers both to improve …
international, multi-center study designed to identify PD progression biomarkers both to improve …
Extinction risk from climate change
Climate change over the past∼ 30 years has produced numerous shifts in the distributions
and abundances of species 1, 2 and has been implicated in one species-level extinction 3. …
and abundances of species 1, 2 and has been implicated in one species-level extinction 3. …
[HTML][HTML] The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung …
…, D Subotic, S Swisher, R Terra, C Thomas… - Journal of Thoracic …, 2016 - Elsevier
The IASLC Staging and Prognostic Factors Committee has collected a new database of
94,708 cases donated from 35 sources in 16 countries around the globe. This has now been …
94,708 cases donated from 35 sources in 16 countries around the globe. This has now been …
[HTML][HTML] Performance of the LHCb RICH detector at the LHC
…, A Sparkes, P Spradlin, B Storaci, C Thomas… - … Physical Journal C, 2013 - Springer
The LHCb experiment has been taking data at the Large Hadron Collider (LHC) at CERN
since the end of 2009. One of its key detector components is the Ring-Imaging Cherenkov (…
since the end of 2009. One of its key detector components is the Ring-Imaging Cherenkov (…
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …
studies; however, a large portion of the genetic risk for this disease remains unexplained. …
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
M Jang, L Cai, GO Udeani, KV Slowing, CF Thomas… - science, 1997 - science.org
Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown
to have cancer chemopreventive activity in assays representing three major stages of …
to have cancer chemopreventive activity in assays representing three major stages of …
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
…, K Dowzell, A Williams, N Jones, C Thomas… - Nature …, 2009 - nature.com
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD)
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …
A 45nm logic technology with high-k+ metal gate transistors, strained silicon, 9 Cu interconnect layers, 193nm dry patterning, and 100% Pb-free packaging
…, S Sivakumar, P Smith, C Thomas… - 2007 IEEE …, 2007 - ieeexplore.ieee.org
A 45 nm logic technology is described that for the first time incorporates high-k + metal gate
transistors in a high volume manufacturing process. The transistors feature 1.0 nm EOT high-…
transistors in a high volume manufacturing process. The transistors feature 1.0 nm EOT high-…