… to recruit and activate proximal components of the c-Jun N-terminal kinase (JNK) pathway;
Ire1α is required for stimulation of c-Jun phosphorylation in response to ER stress [22•]. …

OBJECTIVE: Stroke remains one of the most devastating of all neurological diseases, often
causing death or gross physical impairment or disability. As numerous countries throughout …

… C is also reduced in depression. Clinical studies have shown that increased levels of vitamin
C … Apart from its antioxidant properties, vitamin C (ascorbate) also functions as a cofactor for …

Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently,
in response to oncogenic stimuli, including genotoxic stress. We modified the use of …

The unfolded protein response (UPR) regulates gene expression in response to stress in
the endoplasmic reticulum (ER). We determined the transcriptional scope of the UPR using …

… (c) HCA2 cells were irradiated with 0.5 or 10 Gy and allowed to recover for the indicated
intervals … Data are mean ± sd in a, c, e and f, from three independent measurements in c, e and f. …

The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms.
Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and …

… (c) Northern blot using total RNA isolated from MDA-MB-231 cells as described in (a) was
probed for IRAK1. Reprobing the blot for GAPDH established equal RNA loading. The IRAK1 …

Cellular senescence suppresses cancer by forcing potentially oncogenic cells into a
permanent cell cycle arrest. Senescent cells also secrete growth factors, proteases, and …

… An initial denaturation of 2 min at 950C was followed by 30 to 35 cycles of amplification for
1 min at 95C, 1 min at 55C, 2 min at 720C and a final extension of 7 min at 72C. PCR primer (…