Duchenne muscular dystrophy (DMD) is a severe, progressive disease that affects 1 in 3600–6000
live male births. Although guidelines are available for various aspects of DMD, …

Optimum management of Duchenne muscular dystrophy (DMD) requires a multidisciplinary
approach that focuses on anticipatory and preventive measures as well as active …

Clinical investigations using stem cell products in regenerative medicine are addressing a
wide spectrum of conditions using a variety of stem cell types. To date, there have been few …

Background Anti-TNF drugs are effective treatments for the management of Crohn's disease
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …

… petagrams of carbon (Pg C) per year from streams and rivers and 0.32 Pg C yr −1 from lakes
… The resulting global evasion rate of 2.1 Pg C yr −1 is higher than previous estimates owing …

A permanent human cell line, EA . hy 926, has been established that expresses at least one
highly differentiated function of vascular endothelium, factor VIII-related antigen. This line …

Background Metformin might reduce insulin requirement and improve glycaemia in patients
with type 1 diabetes, but whether it has cardiovascular benefits is unknown. We aimed to …

Agricultural systems models worldwide are increasingly being used to explore options and
solutions for the food security, climate change adaptation and mitigation and carbon trading …

The profile of brain structural abnormalities in schizophrenia is still not fully understood,
despite decades of research using brain scans. To validate a prospective meta-analysis …

Methylation of arginine (Arg) and lysine residues in histones has been correlated with
epigenetic forms of gene regulation. Although histone methyltransferases are known, enzymes …