A principle concern of pharmacovigilance is the timely detection of adverse drug reactions
that are novel by virtue of their clinical nature, severity and/or frequency. The cornerstone of …

… with ‘S only’ compared with ‘S + C’ and that a greater number of drug-event pairs meet or
exceed a numerical ‘signal’ threshold with ‘S only’ compared with ‘S + C’. However, there are …

Topoisomerase I inhibitors constitute a new class of anti-cancer agents. Recently, topotecan
and irinotecan were registered for clinical use in ovarian cancer and colorectal cancer …

… drug C (RR A:C ) and another trial provides the relative response rate of drug B versus … C
(RR B:C ), the relative response rate of drug A versus drug B is estimated as RR A:C /RR B:C . …

The aim of this study was to evaluate the effect of oral N‐acetylcysteine in the prevention of
re-hospitalisation for chronic obstructive pulmonary disease (COPD) exacerbations. Using …

… c Two articles analysed the same trial. d Conferences searched included EASD and ADA
2011–2013, and IDF 2011. IDF 2013 was assessed when the CD-ROM became available—…

Background Recent studies have raised concerns about potential increased cardiovascular
(CV) risk in type 2 diabetes patients treated with some peroxisome proliferator‐activated …

Introduction/Aims Pulmonary decline is a major issue in patients with Duchenne muscular
dystrophy (DMD). Eteplirsen is a United States–approved treatment for patients with DMD and …

Objective: To quantify persistence with inhaled corticosteroids (ICS) among new users in
daily practice and identify determinants of persistence. Methods: A retrospective cohort study …

The restoration of the infiltration capacity of permeable pavers is covered and the hypothesis
that permeable paver infiltration capacities decrease with age and increased traffic use is …