Background Pre-clinical animal studies precede the majority of clinical trials. While the clinical
definitions of sepsis and recommended treatments are regularly updated, a systematic …

Background Inhaled nitric oxide (iNO) has been used for treatment of acute respiratory failure
and pulmonary hypertension since 1991 in adult patients in the perioperative setting and …

… Cardiac output (CO) was measured by thermodilution as the average of two determinations
after injection of 5 ml 0C Ringer's lactate. Pulmonary vascular resistance (PVR) and systemic …

To determine the incidence and 90-d mortality of acute respiratory failure (ARF), acute lung
injury (ALI), and the acute respiratory distress syndrome (ARDS), we carried out an 8-wk …

Objective: To determine whether inhalation of nitric oxide (INO) can increase the frequency
of reversal of acute lung injury (ALI) in nitric oxide (NO) responders. Design: Prospective, …

Background Nitric oxide (NO), an endothelium-derived relaxing factor, acts as a local
vasodilator. The authors examined the effects of NO on pulmonary and systemic circulation in …

The effects of inhaling nitric oxide (NO) on airway mechanics were studied in anesthetized
and mechanically ventilated guinea pigs. In animals without induced bronchoconstriction, …

… CF controls the Claes Frostell Research & Consulting AB company that participated in …
Lankelma JM, van Vught LA, Belzer C, Schultz MJ, van der Poll T, de Vos WM, Wiersinga WJ. …

The anatomical basis of gas exchange impairment in the anaesthetised horse was studied
by computerised tomography (CT; three Shetland ponies) and morphological analysis (one …

… Blomqvist H, Wickerts CJ, Andreen M, Ullberg U, Ortqvist A, Frostell C. Enhanced
pneumonia resolution by inhalation of nitric oxide? Acta Anesthesiol Scand 1992; 37:110-4. …