User profiles for C. M. van Duijn

Cornelia M van Duijn

University of Oxford
Verified email at ndph.ox.ac.uk
Cited by 246274

ACE Polymorphisms

…, BA Oostra, A Isaacs, CM Van Duijn… - Circulation …, 2006 - Am Heart Assoc
Angiotensin converting enzyme (ACE) plays an essential role in two physiological systems,
one leading to the production of angiotensin II and the other to the degradation of bradykinin. …

Genome-based prediction of common diseases: advances and prospects

ACJW Janssens, CM van Duijn - Human molecular genetics, 2008 - academic.oup.com
van Duijnvan Duijnvan Duijn, Genome-based prediction of common diseases: advances
and prospects, Human Molecular Genetics, Volume 17, Issue R2, 15 October 2008, Pages …

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

…, PW Franks, PM Ridker, CM van Duijn… - Molecular …, 2015 - nature.com
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in
the world and has received considerable attention regarding health risks and benefits. We …

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis

…, RH Myers, MA Pericak-Vance, N Risch, CM Van Duijn - Jama, 1997 - jamanetwork.com
Objective. —To examine more closely the association between apolipoprotein E (APOE)
genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and …

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

…, JC van Swieten, A Brice, G Meco, CM van Duijn… - Science, 2003 - science.org
The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1
mutations are associated with PARK7, a monogenic form of human parkinsonism. The function …

GenABEL: an R library for genome-wide association analysis

YS Aulchenko, S Ripke, A Isaacs, CM Van Duijn - Bioinformatics, 2007 - academic.oup.com
Here we describe an R library for genome-wide association (GWA) analysis. It implements
effective storage and handling of GWA data, fast procedures for genetic data quality control, …

[HTML][HTML] Variant of TREM2 Associated with the Risk of Alzheimer's Disease

…, A Hofman, MA Ikram, CM van Duijn… - … England Journal of …, 2013 - Mass Medical Soc
Background Sequence variants, including the ε4 allele of apolipoprotein E, have been
associated with the risk of the common late-onset form of Alzheimer's disease. Few rare variants …

Genome-wide association study of blood pressure and hypertension

…, MG Larson, A Chakravarti, BM Psaty, CM Van Duijn - Nature …, 2009 - nature.com
Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated
with interindividual blood pressure variation have been identified and replicated. Here we …

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

…, CM van Duijn… - Nature …, 2011 - nature.com
We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

…, J Blangero, DE Weeks, B Dhillon, CM van Duijn… - Nature …, 2016 - nature.com
Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the
elderly, with limited therapeutic options. Here we report on a study of >12 million variants, …