Rationale: In human genetic studies a single nucleotide polymorphism within the salt-inducible
kinase 1 (SIK1) gene was associated with hypertension. Lower SIK1 activity in vascular …

Oxidative stress has been hypothesized to play a role in aging and age-related disorders,
such as hypertension. This study compared levels of oxidative stress and renal expression of …

Background: Activation of the sympathetic nervous system is an important feature in
hypertension and congestive heart failure. A strategy for directly modulating sympathetic nerve …

Hyperactivation of the sympathetic nervous system has an important role in the development
and progression of arterial hypertension. This study evaluated the efficacy of etamicastat, a …

The safety, tolerability, pharmacokinetics, and pharmacodynamics of etamicastat (BIA 5–453),
a novel dopamine β‐hydroxylase (DβH) inhibitor, were investigated in 10 sequential …

Overactivity of the sympathetic nervous system has an important role in the development and
progression of arterial hypertension. Catheter-based renal nerve ablation for the treatment …

The interaction of etamicastat, a novel peripherally acting dopamine-β-hydroxylase (DBH)
inhibitor, with the enzyme was studied using a classical kinetic approach and the …

This study explores the impact of permeability and P-glycoprotein (P-gp) efflux, upon brain
exposure to etamicastat, a new dopamine-β-hydroxylase (DBH) inhibitor and consequently …

The aim of the present study was to evaluate the influence of chronic inhibition of dopamine
ß-hydroxylase by etamicastat on the development of hypertension in the spontaneously …

Loss of salt-inducible kinase 1 (SIK1) triggers an increase in blood pressure (BP) upon a
chronic high-salt intake in mice. Here, we further addressed the possible early mechanisms that …