Two-pore domain (K 2P ) channels emerged about a decade ago and since then have been
an expanding area of interest. This is because their biophysical and pharmacological …

Catecholamines play a key role in the regulation of cardiovascular function, classically through
ß 1/2 -adrenoreceptors (AR) activation. After ß 3 -AR cloning in the late 1980s, convincing …

Numerous mediators and drugs regulate blood flow or arterial pressure by acting on vascular
tone, involving cyclic nucleotide intracellular pathways. These signals lead to regulation of …

Background: Myocardial metabolic impairment is a major feature in chronic heart failure. As
the major coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for …

Background Reactive oxygen species and tissue remodeling regulators, such as metalloproteinases
(MMPs) and their inhibitors (TIMPs), are thought to be involved in the development …

Calcium‐activated chloride channels (CaCCs) play important roles in several physiological
processes. In vascular smooth muscle, activation of these ion channels by agonist‐induced …

Background— Mutations in the KCNK3 gene have been identified in some patients suffering
from heritable pulmonary arterial hypertension (PAH). KCNK3 encodes an outward rectifier …

Background— β1-2-adrenergic receptors (AR) are key regulators of cardiac contractility and
remodeling in response to catecholamines. β3-AR expression is enhanced in diseased …

Background: Monoallelic mutations in the gene encoding bone morphogenetic protein receptor
2 (Bmpr2) are the main genetic risk factor for heritable pulmonary arterial hypertension (…

Rationale: Pulmonary arterial hypertension is a severe lethal cardiopulmonary disease. Loss
of function mutations in KCNK3 (potassium channel subfamily K member 3) gene, which …