[HTML][HTML] Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis

…, B Strobel, M Romeike, M Schuler, BE Stierstorfer… - Scientific reports, 2017 - nature.com
Extracellular matrix (ECM) composition and stiffness are major driving forces for the development
and persistence of fibrotic diseases. Lysyl oxidase (LOX) and LOX-like (LOXL) proteins …

[HTML][HTML] Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture

…, RG Crystal, MJ Thomas, B Stierstorfer… - Scientific reports, 2020 - nature.com
Cigarette smoke (CS) is the leading risk factor to develop COPD. Therefore, the pathologic
effects of whole CS on the differentiation of primary small airway epithelial cells (SAEC) were …

[HTML][HTML] Quantification of pulmonary fibrosis in a bleomycin mouse model using automated histological image analysis

JC Gilhodes, Y Julé, S Kreuz, B Stierstorfer, D Stiller… - PloS one, 2017 - journals.plos.org
Current literature on pulmonary fibrosis induced in animal models highlights the need of an
accurate, reliable and reproducible histological quantitative analysis. One of the major limits …

[HTML][HTML] Deep learning enables pathologist-like scoring of NASH models

F Heinemann, G Birk, B Stierstorfer - Scientific reports, 2019 - nature.com
Non-alcoholic fatty liver disease (NAFLD) and the progressive form of non-alcoholic
steatohepatitis (NASH) are diseases of major importance with a high unmet medical need. Efficacy …

[PDF][PDF] Human stem cell-based retina on chip as new translational model for validation of AAV retinal gene therapy vectors

…, MJ Düchs, C Schön, S Michelfelder, B Stierstorfer… - Stem cell reports, 2021 - cell.com
Gene therapies using adeno-associated viruses (AAVs) are among the most promising
strategies to treat or even cure hereditary and acquired retinal diseases. However, the …

Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in a human iPSC‐derived air‐liquid interface model

…, MJ Webster, M Dass, M Frick, B Stierstorfer… - The FASEB …, 2020 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a fatal disease of unknown cause that is characterized
by progressive fibrotic lung remodeling. An abnormal emergence of airway epithelial‐like …

[HTML][HTML] Quantitative profiling of the human substantia nigra proteome from laser-capture microdissected FFPE tissue

E Griesser, H Wyatt, S Ten Have, B Stierstorfer… - Molecular & Cellular …, 2020 - ASBMB
Laser-capture microdissection (LCM) allows the visualization and isolation of morphologically
distinct subpopulations of cells from heterogeneous tissue specimens. In combination with …

[HTML][HTML] Cigarette smoke specifically affects small airway epithelial cell populations and triggers the expansion of inflammatory and squamous differentiation …

…, T Kiechle, Y Shen, GG Leparc, B Stierstorfer… - International Journal of …, 2021 - mdpi.com
Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD) and causes
remodeling of the small airways. However, the exact smoke-induced effects on the different …

[HTML][HTML] SGLT2 is not expressed in pancreatic α-and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

…, F Khattab, BK Lai, D Brusa, B Stierstorfer… - Molecular …, 2020 - Elsevier
Objective Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i), or gliflozins, are anti-diabetic
drugs that lower glycemia by promoting glucosuria, but they also stimulate …

Modeling pulmonary disease pathways using recombinant adeno-associated virus 6.2

…, MJ Duechs, R Schmid, BE Stierstorfer… - American journal of …, 2015 - atsjournals.org
Viral vectors have been applied successfully to generate disease-related animal models and
to functionally characterize target genes in vivo. However, broader application is still limited …