User profiles for Bertrand DeMeulder

Bertrand De Meulder

EISBM
Verified email at eisbm.org
Cited by 2487

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

D Lefaudeux, B De Meulder, MJ Loza, N Peffer… - Journal of Allergy and …, 2017 - Elsevier
Background Asthma is a heterogeneous disease in which there is a differential response to
asthma treatments. This heterogeneity needs to be evaluated so that a personalized …

Systems medicine: the future of medical genomics, healthcare, and wellness

…, I Roznovat, A Mazein, S Ballereau, B De Meulder… - Systems Medicine, 2016 - Springer
Recent advances in genomics have led to the rapid and relatively inexpensive collection of
patient molecular data including multiple types of omics data. The integration of these data …

Introducing PIONEER: a project to harness big data in prostate cancer research

…, R Campi, M Cavelaars, B De Meulder… - Nature Reviews …, 2020 - nature.com
Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in
Europe (PIONEER) is a European network of excellence for big data in prostate cancer, …

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED

…, N Krug, T Sandstrӧm, B De Meulder… - American journal of …, 2017 - atsjournals.org
Rationale: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory
mechanisms. Objectives: Using transcriptomic profiling of airway tissues, we sought to …

[HTML][HTML] Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

…, JA Ward, A Chauhan, AR Sousa, B De Meulder… - Journal of allergy and …, 2019 - Elsevier
Background Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R)
to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in …

“T2-high” in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin

…, J Corfield, C Auffray, B De Meulder… - European …, 2019 - Eur Respiratory Soc
Type-2 (T2) immune responses in airway epithelial cells (AECs) classifies mild–moderate
asthma into a T2-high phenotype. We examined whether currently available clinical …

Pathway discovery using transcriptomic profiles in adult-onset severe asthma

PP Hekking, MJ Loza, S Pavlidis, B De Meulder… - Journal of Allergy and …, 2018 - Elsevier
Background Adult-onset severe asthma is characterized by highly symptomatic disease
despite high-intensity asthma treatments. Understanding of the underlying pathways of this …

Combined effects of deltamethrin, temperature and salinity on oxidative stress biomarkers and acetylcholinesterase activity in the black tiger shrimp (Penaeus …

HT Tu, F Silvestre, B De Meulder, JP Thome… - Chemosphere, 2012 - Elsevier
This study aimed to investigate the interactions of two abiotic factors (temperature and salinity)
and deltamethrin (pyrethroid pesticide) exposure on some oxidative stress biomarkers as …

[HTML][HTML] Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms

…, N Le Novère, D Lefaudeux, B De Meulder… - NPJ systems biology …, 2018 - nature.com
The development of computational approaches in systems biology has reached a state of
maturity that allows their transition to systems medicine. Despite this progress, intuitive …

Identification and prospective stability of electronic nose (eNose)–derived inflammatory phenotypes in patients with severe asthma

…, M Santonico, D Lefaudeux, B De Meulder… - Journal of Allergy and …, 2019 - Elsevier
Background Severe asthma is a heterogeneous condition, as shown by independent cluster
analyses based on demographic, clinical, and inflammatory characteristics. A next step is to …