User profiles for Bertrand DeMeulder
Bertrand De MeulderEISBM Verified email at eisbm.org Cited by 2487 |
U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics
D Lefaudeux, B De Meulder, MJ Loza, N Peffer… - Journal of Allergy and …, 2017 - Elsevier
Background Asthma is a heterogeneous disease in which there is a differential response to
asthma treatments. This heterogeneity needs to be evaluated so that a personalized …
asthma treatments. This heterogeneity needs to be evaluated so that a personalized …
Systems medicine: the future of medical genomics, healthcare, and wellness
Recent advances in genomics have led to the rapid and relatively inexpensive collection of
patient molecular data including multiple types of omics data. The integration of these data …
patient molecular data including multiple types of omics data. The integration of these data …
Introducing PIONEER: a project to harness big data in prostate cancer research
…, R Campi, M Cavelaars, B De Meulder… - Nature Reviews …, 2020 - nature.com
Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in
Europe (PIONEER) is a European network of excellence for big data in prostate cancer, …
Europe (PIONEER) is a European network of excellence for big data in prostate cancer, …
A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED
…, N Krug, T Sandstrӧm, B De Meulder… - American journal of …, 2017 - atsjournals.org
Rationale: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory
mechanisms. Objectives: Using transcriptomic profiling of airway tissues, we sought to …
mechanisms. Objectives: Using transcriptomic profiling of airway tissues, we sought to …
[HTML][HTML] Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
…, JA Ward, A Chauhan, AR Sousa, B De Meulder… - Journal of allergy and …, 2019 - Elsevier
Background Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R)
to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in …
to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in …
“T2-high” in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin
…, J Corfield, C Auffray, B De Meulder… - European …, 2019 - Eur Respiratory Soc
Type-2 (T2) immune responses in airway epithelial cells (AECs) classifies mild–moderate
asthma into a T2-high phenotype. We examined whether currently available clinical …
asthma into a T2-high phenotype. We examined whether currently available clinical …
Pathway discovery using transcriptomic profiles in adult-onset severe asthma
PP Hekking, MJ Loza, S Pavlidis, B De Meulder… - Journal of Allergy and …, 2018 - Elsevier
Background Adult-onset severe asthma is characterized by highly symptomatic disease
despite high-intensity asthma treatments. Understanding of the underlying pathways of this …
despite high-intensity asthma treatments. Understanding of the underlying pathways of this …
Combined effects of deltamethrin, temperature and salinity on oxidative stress biomarkers and acetylcholinesterase activity in the black tiger shrimp (Penaeus …
This study aimed to investigate the interactions of two abiotic factors (temperature and salinity)
and deltamethrin (pyrethroid pesticide) exposure on some oxidative stress biomarkers as …
and deltamethrin (pyrethroid pesticide) exposure on some oxidative stress biomarkers as …
[HTML][HTML] Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms
…, N Le Novère, D Lefaudeux, B De Meulder… - NPJ systems biology …, 2018 - nature.com
The development of computational approaches in systems biology has reached a state of
maturity that allows their transition to systems medicine. Despite this progress, intuitive …
maturity that allows their transition to systems medicine. Despite this progress, intuitive …
Identification and prospective stability of electronic nose (eNose)–derived inflammatory phenotypes in patients with severe asthma
…, M Santonico, D Lefaudeux, B De Meulder… - Journal of Allergy and …, 2019 - Elsevier
Background Severe asthma is a heterogeneous condition, as shown by independent cluster
analyses based on demographic, clinical, and inflammatory characteristics. A next step is to …
analyses based on demographic, clinical, and inflammatory characteristics. A next step is to …