User profiles for Bart Ghesquière

Bart Ghesquiere

Head of Metabolomics Expertise Center, KULeuven-VIB
Verified email at kuleuven.vib.be
Cited by 13735

Metabolites released from apoptotic cells act as tissue messengers

…, Y Guo, S Morioka, B Barron, SF Walk, B Ghesquière… - Nature, 2020 - nature.com
Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover
in the body 1 , and regulates inflammation, cell proliferation, and tissue regeneration 2 , 3 – …

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

…, F D'Anna, A Kuchnio, A Ploumakis, B Ghesquière… - Nature, 2016 - nature.com
Hypermethylation of the promoters of tumour suppressor genes represses transcription of
these genes, conferring growth advantages to cancer cells. How these changes arise is poorly …

[HTML][HTML] Consensus guidelines for the use and interpretation of angiogenesis assays

…, N Ferrara, M Fruttiger, D Fukumura, B Ghesquière… - Angiogenesis, 2018 - Springer
The formation of new blood vessels, or angiogenesis, is a complex process that plays important
roles in growth and development, tissue and organ regeneration, as well as numerous …

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

…, M Dewerchin, M Baes, K De Bock, B Ghesquière… - Nature, 2015 - nature.com
The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here
we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), …

[HTML][HTML] Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

…, WA Baseler, LC Davies, B Ghesquière… - Nature …, 2020 - nature.com
Profound metabolic changes are characteristic of macrophages during classical activation
and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) …

A roadmap for interpreting 13C metabolite labeling patterns from cells

…, O Feron, C Frezza, B Ghesquiere… - Current opinion in …, 2015 - Elsevier
Highlights • 13 C tracer analysis can be used to probe intracellular metabolism in cells. •
Steady state labeling patterns can quantify nutrient contributions. • Steady state labeling …

[HTML][HTML] Role of PFKFB3-driven glycolysis in vessel sprouting

…, AR Cantelmo, A Quaegebeur, B Ghesquiere… - Cell, 2013 - cell.com
Vessel sprouting by migrating tip and proliferating stalk endothelial cells (ECs) is controlled
by genetic signals (such as Notch), but it is unknown whether metabolism also regulates this …

[PDF][PDF] Inhibition of the glycolytic activator PFKFB3 in endothelium induces tumor vessel normalization, impairs metastasis, and improves chemotherapy

…, L Schoonjans, T Rabelink, G Eelen, B Ghesquière… - Cancer cell, 2016 - cell.com
Abnormal tumor vessels promote metastasis and impair chemotherapy. Hence, tumor vessel
normalization (TVN) is emerging as an anti-cancer treatment. Here, we show that tumor …

[PDF][PDF] Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis

…, AR Cantelmo, M Georgiadou, B Ghesquière… - Cell metabolism, 2014 - cell.com
Strategies targeting pathological angiogenesis have focused primarily on blocking vascular
endothelial growth factor (VEGF), but resistance and insufficient efficacy limit their success, …

[HTML][HTML] Tumor vessel normalization by chloroquine independent of autophagy

…, H Gerhardt, E Dejana, M Dewerchin, B Ghesquiere… - Cancer cell, 2014 - cell.com
Chloroquine (CQ) has been evaluated as an autophagy blocker for cancer treatment, but it
is unknown if it acts solely by inhibiting cancer cell autophagy. We report that CQ reduced …