Sustained plasma hepcidin suppression and iron elevation by Anticalin‐derived hepcidin antagonist in cynomolgus monkey

…, M Kolodziejczyk, B Rattenstetter… - British journal of …, 2018 - Wiley Online Library
Background and Purpose Anaemia of chronic disease (ACD) has been linked to iron‐restricted
erythropoiesis imposed by high circulating levels of hepcidin, a 25 amino acid hepatocyte…

[HTML][HTML] Elarekibep (PRS-060/AZD1402), a new class of inhaled Anticalin medicine targeting IL-4Ra for type 2 endotype asthma

…, H Gille, K Jensen, K Kirchfeld, B Rattenstetter… - Journal of Allergy and …, 2023 - Elsevier
Background Type 2 endotype asthma is driven by IL-4 and IL-13 signaling via IL-4Ra, which
is highly expressed on airway epithelium, airway smooth muscle, and immunocytes in the …

The Discovery and Development of AZD1402/PRS-060, an Inhaled, Potent and Selective Antagonist of the IL-4 Receptor Alpha

G Matschiner, S Huang, S Constant, B Rattenstetter… - 2018 - Eur Respiratory Soc
Antagonising the IL-4 receptor α (IL-4Rα) interferes with downstream IL-4/IL-13 signalling
and clinically has beneficial effects in moderate to severe asthma. Anticalin® proteins are …

Exploiting Lipocalin Biochemistry For The Treatment Of Allergy And Asthma: Discovery And Characterization Of An Anti-IL-4RA Therapeutic

…, G Matschiner, B Rattenstetter… - C21. NEW TARGETS …, 2011 - atsjournals.org
Methods Randomization of Anticalin binding loops and affinity based phage display selection
was used to achieve low picomolar potency against hIL4Ra. The human IL-4Ra Anticalin …

A reliable and long shelf-life in vitro cell model for studying goblet cell metaplasia in the human airways

S Huang, A Hohlbaum, B Rattenstetter, L Wiszniewski… - 2012 - Eur Respiratory Soc
Goblet cell metaplasia, induced mainly by TH-2 cytokines like IL-13 and IL-4, is a common
feature of several respiratory diseases such as asthma, COPD, and Cystic fibrosis. Recent …

[CITATION][C] Iron mobilization and pharmacodynic marker measurements in non-human primates following administration of PRS-080, a novel and highly specific anti …

…, J Burrows, B Rattenstetter… - American …, 2013 - … ST, HOBOKEN 07030-5774, NJ USA