Background Interleukin-5 (IL-5) is essential for the formation of eosinophils, which are thought
to have a major role in the pathogenesis of asthma and other allergic diseases. We aimed …

Antagonizing the effect of interleukin (IL)-5 is a potential new treatment strategy in allergic
disorders. We evaluated the safety, biological activity, and pharmacokinetics of SCH55700 , a …

Background Inhaled glucocorticoids and oral theophylline are widely used to treat asthma.
We compared the benefits of adding theophylline to inhaled glucocorticoid with those of …

Background Interleukin-12 (IL-12) is a macrophage-derived cytokine that modulates T
lymphocyte responses and has the capacity to suppress allergic and eosinophilic inflammation. …

OBJECTIVE: The reported incidence of adenocarcinoma in Barrett's esophagus is variable.
The aim of this study was to determine the incidence of dysplasia and adenocarcinoma in a …

Background. Tolerance to the direct bronchodilator effects of β 2 -agonists does not appear
to occur in asthma. However, it is not known whether this is true for the nonbronchodilator …

Bronchiectasis is characterized by chronic inflammation in one or more bronchi, but the extent
of inflammation is difficult to monitor. The concentration of nitric oxide (NO) in exhaled air …

BACKGROUND: Class switching from IgM/IgG/IgA to IgE is required for B cells to express
IgE. This requires class switch recombination in the Ig heavy-chain gene locus. It is generally …

… BJ O’Connor5 … The authors would like to thank the investigators, SD Singh (Manchester),
B O'Connor (London), R Djukanovic (Southampton), W Wedzicha (London), G Joos (Gent, …

The concentration of nitric oxide (NO) is increased in the exhaled air of asthmatic patients
and may reflect cytokine-mediated inflammation in the airways. We investigated whether …