In vivo animal models can offer valuable information on several aspects of asthma pathogenesis
and treatment. The mouse is increasingly used in these models, mainly because this …

Airway hyperreactivity (AHR), eosinophilic inflammation with a Th2-type cytokine profile, and
specific Th2-mediated IgE production characterize allergic asthma. In this paper, we show …

The factors that contribute to allergic asthma are unclear but the resulting condition is
considered a consequence of a type-2 T helper (T H 2) cell response. In a model of pulmonary …

PLATELET aggregation is mediated by at least three distinct mechanisms 1,2 . The first
involves the release of ADP and is inhibited by its conversion to ATP by the combination of …

This report examines the effect of recombinant murine (rm) IL-10 on antigen-induced cellular
recruitment into the airways of sensitized Balb/c mice. The intranasal instillation of 10 …

Asthma results from an intrapulmonary allergen-driven Th2 response and is characterized by
intermittent airway obstruction, airway hyperreactivity, and airway inflammation. An inverse …

… & Vargaftig, BB Eosinophil recruitment into the respiratory epithelium following antigenic
challenge in hyper-IgE mice is accompanied by interleukin-5-… B Boris Vargaftig … B Boris …

Lyso-phospholipids exert a major injurious effect on lung cell membranes during Acute
Respiratory Distress Syndrome (ARDS), but the mechanisms leading to their in vivo generation …

… 5), indicating, as shown previously for ATP, ADP and collagen (Lefort and Vargaftig, 1978), …
and BB Vargaftig, 1978, Role of platelets in aspirin-sensitive bronchoconstriction in the gui…

In this study we examined the effect of oral antigen (Ag) administration on the development
of experimental asthma in different mouse strains. We selected BALB / c, BP2, CBA / Ca …