Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical, …

… b | Chemical structures of ACE inhibitors currently used in the clinic. c | Structure of ACE–lisinopril
complex. Coordinates were taken from the Protein Data Bank (entry code 1O86). …

… In cathepsin B, an irreversible loss of activity accompanied by … However, after the binding
of heparin to cathepsin B through an … Twenty years ago, it was demonstrated that cathepsin B, …

AMPK is a highly conserved sensor of cellular energy status that is activated under conditions
of low intracellular ATP. AMPK responds to energy stress by suppressing cell growth and …

… the cathepsin B family, as the two insertions (a three residue insertion in the 19–21 region
and the ‘occluding’ loop insertion) may, similarly to the occluding loop in cathepsin B, tighten …

… Bonds of substrate and cathepsin B structure are shown in cyan and green, respectively. …
B and substrate models. The GRASP generated surface (Nicholls et al., 1991) of cathepsin …

… The enzymes, except cathepsin C, are endopeptidases (reviewed in Kirschke et al., 1995),
although cathepsin B was found also to be a dipeptidyl carboxypeptidase (Aronson and …

Protein phosphorylation is one of the most widespread post-translational modifications in
biology 1 , 2 . With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of …

We investigated the mechanism of lysosome-mediated cell death using purified recombinant
pro-apoptotic proteins, and cell-free extracts from the human neuronal progenitor cell line …

The number of known proteases is increasing at a tremendous rate as a consequence of
genome sequencing projects. Although one can guess at the functions of these novel enzymes …