Regulators of A20 (TNFAIP3): new drug-able targets in inflammation

…, JR Naranjo, BC Schock - American Journal of …, 2019 - journals.physiology.org
Persistent activation of the transcription factor Nuclear factor-κB (NF-κB) is central to the
pathogenesis of many inflammatory disorders, including those of the lung such as cystic fibrosis (…

Bronchoalveolar lavage findings suggest two different forms of childhood asthma

…, G Turner, LG Heaney, BC Schock… - Clinical & …, 1997 - Wiley Online Library
Background It seems plausible that children with atopy and persistent asthma symptoms will,
like their adult counterparts, have chronic airways inflammation. However, many young …

Post-traumatic stress disorder: focus on neuroinflammation

J Li, L Tong, BC Schock, LL Ji - Molecular Neurobiology, 2023 - Springer
Post-traumatic stress disorder (PTSD), gaining increasing attention, is a multifaceted psychiatric
disorder that occurs following a stressful or traumatic event or series of events. Recently, …

Ozone exposure activates oxidative stress responses in murine skin

G Valacchi, A Van der Vliet, BC Schock, T Okamoto… - Toxicology, 2002 - Elsevier
Ozone (O 3 ) is among the most reactive environmental oxidant to which skin is exposed. O
3 exposure has previously been shown to induce antioxidant depletion as well as lipid and …

Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in α-tocopherol transfer protein

K Gohil, BC Schock, AA Chakraborty… - Free radical biology and …, 2003 - Elsevier
Alpha-tocopherol transfer protein (TTP) regulates the retention and secretion of α-tocopherol
(α-T) by the liver. Deletion of the TTP gene (Ttpa) in mice results in systemic deficiency of α-…

Neutrophils and eosinophils: clinical implications of their appearance, presence and disappearance in asthma and COPD.

AP Watt, BC Schock, M Ennis - Current drug targets. Inflammation …, 2005 - europepmc.org
Asthma and chronic obstructive pulmonary disease (COPD) are common chronic disorders.
Traditionally, asthma has been associated with an eosinophilic inflammation and COPD with …

Increased concentrations of the oxidative DNA adduct 7, 8-dihydro-8-oxo-2-deoxyguanosine in the germ-line of men with type 1 diabetes

IM Agbaje, CM McVicar, BC Schock, N McClure… - Reproductive …, 2008 - Elsevier
The effects of diabetes mellitus on male reproductive health have not been clearly defined.
A previous publication from this group reported significantly higher levels of nuclear DNA …

Effect of fruit and vegetable intake on oxidative stress and inflammation in COPD: a randomised controlled trial

…, JM Bradley, CC Patterson, BC Schock… - European respiratory …, 2012 - Eur Respiratory Soc
Epidemiological evidence supports a positive relationship between fruit and vegetable (FV)
intake, lung function and chronic obstructive pulmonary disease (COPD). Increasing FV …

Chronic cough in children: bronchoalveolar lavage findings

PS Fitch, V Brown, BC Schock, R Taylor… - European …, 2000 - Eur Respiratory Soc
Isolated chronic cough in childhood is a common complaint. Although the symptom cough is
included in the definition of clildhood asthma, there is debate as to whether the majoritv of …

Connectivity mapping (ssCMap) to predict A20-inducing drugs and their antiinflammatory action in cystic fibrosis

…, C Kelly, SD Zhang, BC Schock - Proceedings of the …, 2016 - National Acad Sciences
Cystic fibrosis (CF) lung disease is characterized by chronic and exaggerated inflammation
in the airways. Despite recent developments to therapeutically overcome the underlying …