Hedgehog pathway and its inhibitors in chronic obstructive pulmonary disease (COPD)

Z Lahmar, E Ahmed, A Fort, I Vachier, A Bourdin… - Pharmacology & …, 2022 - Elsevier
COPD affects millions of people and is now ranked as the third leading cause of death
worldwide. This largely untreatable chronic airway disease results in irreversible destruction of …

Targeted therapy in eosinophilic chronic obstructive pulmonary disease

…, C Bourguignon, S Assou, A Nasri, A Fort… - ERJ Open …, 2021 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is a common and preventable airway
disease causing significant worldwide mortality and morbidity. Lifetime exposure to tobacco …

Terlipressin, a provasopressin drug exhibits direct vasoconstrictor properties: consequences on heart perfusion and performance

F Ryckwaert, A Virsolvy, A Fort, B Murat… - Critical care …, 2009 - journals.lww.com
Objective: Terlipressin has been proposed as an alternative treatment to catecholamines to
restore blood pressure in septic shock. Terlipressin is considered as a vasopressin prodrug …

[HTML][HTML] Endothelin-dependent vasoconstriction in human uterine artery: application to preeclampsia

C Dechanet, A Fort, E Barbero-Camps, H Dechaud… - PloS one, 2011 - journals.plos.org
Background Reduced uteroplacental perfusion, the initiating event in preeclampsia, is
associated with enhanced endothelin-1 (ET-1) production which feeds the vasoconstriction of …

Mucus from human bronchial epithelial cultures: rheology and adhesion across length scales

…, C Blanc, K Bellouma, A Fort… - Interface …, 2022 - royalsocietypublishing.org
Mucus is a viscoelastic aqueous fluid that participates in the protective barrier of many
mammals' epithelia. In the airways, together with cilia beating, mucus rheological properties are …

[HTML][HTML] New Insights in the Contribution of Voltage-Gated Nav Channels to Rat Aorta Contraction

A Fort, M Cordaillat, C Thollon, G Salazar, I Mechaly… - PLoS …, 2009 - journals.plos.org
Background Despite increasing evidence for the presence of voltage-gated Na + channels (Na
v ) isoforms and measurements of Na v channel currents with the patch-clamp technique …

Club cells and CC16: another “smoking gun”?(With potential bullets against COPD)

L Knabe, A Fort, P Chanez… - European Respiratory …, 2015 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) remains a challenge for clinicians and
scientists, as no currently available treatment can significantly change the natural history of the …

[HTML][HTML] Hypoxic conditions promote rhythmic contractile oscillations mediated by voltage-gated sodium channels activation in human arteries

A Virsolvy, A Fort, L Erceau, A Charrabi… - International Journal of …, 2021 - mdpi.com
Arterial smooth muscle exhibits rhythmic oscillatory contractions called vasomotion and
believed to be a protective mechanism against tissue hypoperfusion or hypoxia. Oscillations of …

Use of 3D surface scanning to match facial shapes against altered exhumed remains in a context of forensic individual identification

P Charlier, P Froesch, I Huynh-Charlier, A Fort… - … Science, Medicine, and …, 2014 - Springer
Objective 3D surface scanning has been successfully used in forensic medicine and
pathology for over a decade. We report a new application area: a technique of skull-face …

Diastolic cardiomyopathy secondary to experimentally induced exacerbated emphysema

…, Q Wynands, F Gouzi, P Bideaux, A Fort… - American Journal of …, 2023 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a clinical entity of increasing significance.
COPD involves abnormalities of the airways and, in emphysema, parenchymal pulmonary …